Evoked corticospinal output to the human scalene muscles is altered by lung volume

Anna L. Hudson; Janet L. Taylor; Ashima Anand; Simon C. Gandevia; Jane E. Butler

doi:10.1016/j.resp.2011.11.017

Evoked corticospinal output to the human scalene muscles is altered by lung volume

Anna L. Hudson, Janet L. Taylor, Ashima Anand, Simon C. Gandevia, Jane E. Butler

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Increases in lung volume inhibit the inspiratory output from the medulla, but the effect of lung inflation on the voluntary control of breathing in humans is not known. We tested corticospinal excitability using transcranial magnetic stimulation (TMS) to evoke a response in the scalene muscles. TMS was delivered at rest at three different lung volumes between functional residual capacity (FRC) and total lung capacity (TLC) during incremental inspiratory and incremental expiratory manoeuvres. Motor evoked potentials (MEPs) in scalenes were ∼50% larger at a high lung volume (FRC + ∼90% inspiratory capacity [IC]) compared to lower lung volumes (FRC and FRC + ∼40% IC) in both inspiratory and expiratory manoeuvres (p< 0.001). The change in MEP size was not due to differences in pre-stimulus EMG amplitude (p= 0.29). The results suggest a differential effect of lung inflation on the automatic and voluntary control of breathing in humans.

Original language	English
Pages (from-to)	263-268
Number of pages	6
Journal	Respiratory Physiology and Neurobiology
Volume	180
Issue number	2-3
DOIs	https://doi.org/10.1016/j.resp.2011.11.017
Publication status	Published - 15 Mar 2012
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by grants from the National Health and Medical Research Council (Australia) and the Department of Science and Technology (India) .

Keywords

Inspiratory muscles
Lung inflation
Motor cortical excitability

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title = "Evoked corticospinal output to the human scalene muscles is altered by lung volume",

abstract = "Increases in lung volume inhibit the inspiratory output from the medulla, but the effect of lung inflation on the voluntary control of breathing in humans is not known. We tested corticospinal excitability using transcranial magnetic stimulation (TMS) to evoke a response in the scalene muscles. TMS was delivered at rest at three different lung volumes between functional residual capacity (FRC) and total lung capacity (TLC) during incremental inspiratory and incremental expiratory manoeuvres. Motor evoked potentials (MEPs) in scalenes were ∼50% larger at a high lung volume (FRC + ∼90% inspiratory capacity [IC]) compared to lower lung volumes (FRC and FRC + ∼40% IC) in both inspiratory and expiratory manoeuvres (p< 0.001). The change in MEP size was not due to differences in pre-stimulus EMG amplitude (p= 0.29). The results suggest a differential effect of lung inflation on the automatic and voluntary control of breathing in humans.",

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AU - Hudson, Anna L.

AU - Taylor, Janet L.

AU - Anand, Ashima

AU - Gandevia, Simon C.

AU - Butler, Jane E.

N1 - Funding Information: This work was supported by grants from the National Health and Medical Research Council (Australia) and the Department of Science and Technology (India) .

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N2 - Increases in lung volume inhibit the inspiratory output from the medulla, but the effect of lung inflation on the voluntary control of breathing in humans is not known. We tested corticospinal excitability using transcranial magnetic stimulation (TMS) to evoke a response in the scalene muscles. TMS was delivered at rest at three different lung volumes between functional residual capacity (FRC) and total lung capacity (TLC) during incremental inspiratory and incremental expiratory manoeuvres. Motor evoked potentials (MEPs) in scalenes were ∼50% larger at a high lung volume (FRC + ∼90% inspiratory capacity [IC]) compared to lower lung volumes (FRC and FRC + ∼40% IC) in both inspiratory and expiratory manoeuvres (p< 0.001). The change in MEP size was not due to differences in pre-stimulus EMG amplitude (p= 0.29). The results suggest a differential effect of lung inflation on the automatic and voluntary control of breathing in humans.

AB - Increases in lung volume inhibit the inspiratory output from the medulla, but the effect of lung inflation on the voluntary control of breathing in humans is not known. We tested corticospinal excitability using transcranial magnetic stimulation (TMS) to evoke a response in the scalene muscles. TMS was delivered at rest at three different lung volumes between functional residual capacity (FRC) and total lung capacity (TLC) during incremental inspiratory and incremental expiratory manoeuvres. Motor evoked potentials (MEPs) in scalenes were ∼50% larger at a high lung volume (FRC + ∼90% inspiratory capacity [IC]) compared to lower lung volumes (FRC and FRC + ∼40% IC) in both inspiratory and expiratory manoeuvres (p< 0.001). The change in MEP size was not due to differences in pre-stimulus EMG amplitude (p= 0.29). The results suggest a differential effect of lung inflation on the automatic and voluntary control of breathing in humans.

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Evoked corticospinal output to the human scalene muscles is altered by lung volume

Abstract

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Keywords

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