Abstract
Introduction: This study delves into the intricate relationship between depression and brain structure in individuals with Multiple Sclerosis (MS). Recognizing the notable prevalence of depression in the MS population and its impact on overall well-being, the research aims to unravel the underlying neurobiological mechanisms through advanced neuroimaging techniques.
Objectives: The study pursues multiple objectives, including investigating the correlation between depression severity and gray matter atrophy, identifying localized structural changes associated with depression in MS, analyzing the impact of disease-related variables, and enhancing the understanding of the interplay between depressive symptoms and brain structure.
Methods: Employing a mixed-methods research design, the study engages a sample of 14 MS patients from a Tertiary Care Hospital in Islamabad. Quantitative data from surveys, utilizing the Beck Depression Inventory, and MRI reports are complemented by qualitative insights gained through thematic analysis. This comprehensive approach ensures a nuanced exploration of the correlation between depression and brain structure.
Results: The findings reveal a diverse demographic composition, varied educational backgrounds, and distinct levels of depression within the study cohort. Thematic analysis uncovers commonalities, including the absence of acute pathologies, sinus mucosal disease, and stable or minimally improved demyelinating lesions across different depression levels. These results contribute valuable insights to the multidimensional impact of MS on both physical and mental health.
Conclusion: In conclusion, the study underscores the interconnectedness of depression and structural brain changes in MS patients. The observed patterns highlight the need for a holistic approach to patient care, recognizing the dynamic nature of MS lesions and the varied impact of depression. The findings also suggest potential avenues for targeted interventions, emphasizing the importance of addressing both physical and mental aspects in MS management.
Objectives: The study pursues multiple objectives, including investigating the correlation between depression severity and gray matter atrophy, identifying localized structural changes associated with depression in MS, analyzing the impact of disease-related variables, and enhancing the understanding of the interplay between depressive symptoms and brain structure.
Methods: Employing a mixed-methods research design, the study engages a sample of 14 MS patients from a Tertiary Care Hospital in Islamabad. Quantitative data from surveys, utilizing the Beck Depression Inventory, and MRI reports are complemented by qualitative insights gained through thematic analysis. This comprehensive approach ensures a nuanced exploration of the correlation between depression and brain structure.
Results: The findings reveal a diverse demographic composition, varied educational backgrounds, and distinct levels of depression within the study cohort. Thematic analysis uncovers commonalities, including the absence of acute pathologies, sinus mucosal disease, and stable or minimally improved demyelinating lesions across different depression levels. These results contribute valuable insights to the multidimensional impact of MS on both physical and mental health.
Conclusion: In conclusion, the study underscores the interconnectedness of depression and structural brain changes in MS patients. The observed patterns highlight the need for a holistic approach to patient care, recognizing the dynamic nature of MS lesions and the varied impact of depression. The findings also suggest potential avenues for targeted interventions, emphasizing the importance of addressing both physical and mental aspects in MS management.
| Original language | English |
|---|---|
| Pages (from-to) | 435-444 |
| Number of pages | 10 |
| Journal | Journal of Population Therapeutics and Clinical Pharmacology, |
| Volume | 31 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2 Feb 2024 |
| Externally published | Yes |
Keywords
- Multiple Sclerosis
- depression
- brain structure
- MRI
- thematic analysis