Excessive Daytime Sleepiness, Undiagnosed Obstructive Sleep Apnea, Quality of Life And Comorbidities In A Population-Based Cohort Of Men

Sarah L Appleton, Andrew Vakulin, Carol Lang, Gary Wittert, Sean A Martin, Janet Grant, Anne W Taylor, Peter G Catcheside, Nick Antic, Doug McEvoy, Robert Adams

    Research output: Contribution to journalMeeting Abstractpeer-review

    Abstract

    Introduction: Excessive daytime sleepiness (EDS), while not common in obstructive sleep apnea (OSA), may identify those at greatest risk for cardio-metabolic disease and quality of life impairments. We therefore determined predictors of EDS in a male population-based cohort, the impact of EDS on SF-36 quality of life and whether EDS modifies the relationship of undiagnosed OSA with comorbidities. Methods: In 2011–12, 826 participants without a prior OSA diagno-sis from the Men Androgen Inflammation Lifestyle Environment and Stress Study (n = 1869, ≥ 40 yrs, Adelaide, Australia), underwent full in-home polysomnography (Embletta X100) and completed the Ep-worth Sleepiness Scale (ESS), SF-36 questionnaire, biomedical assess-ment and questionnaires assessing doctor diagnosed conditions.Results: EDS (ESS ≥ 11, 12.6%, n = 104) was not significantly dif-ferent across categories of OSA severity (AHI < 10/h = 11.2%, 10–19/h = 13.7%, 20–29/h = 14.8%, ≥ 30/h = 13.1%, p = 0.69) or body mass index (p = 0.89). No associations were seen with oxygen desatu-ration, time with oxygen saturation < 90%, total arousals, metabolic parameters (blood pressure, lipids) or sociodemographics. In logistic regression analyses, EDS was significantly associated with depression: odds ratio (OR), 95% CI: 2.16 (1.28–3.66), nocturia:2.09 (1.32–3.32) and borderline associations were seen with diabetes:1.67 (0.97–2.87) and age 50–69 y:1.65 (0.97–2.81). ESS scores were significant inde-pendent predictors of SF-36 physical (PCS) and mental component summary (MCS) scores in men < 70 years but not in men ≥ 70 years and scores were attenuated when men with depression were excluded [unstandardised B (95% CI) PCS: −0.19 (−0.35, −0.22), MCS: −0.15 (−0.30, 0.004)]. Significant associations of OSA and cardio-metabolic conditions were seen but only depression and diabetes were signifi-cantly more frequent in men with OSA and EDS.Conclusion: EDS was uncommon in a population-based cohort of men, was related to depression and nocturia but not undiagnosed OSA. EDS modified the association of OSA and depression and diabetes. Significant independent EDS-related impairments in SF-36 scores in men < 70 y need to be identified and addressed.
    Original languageEnglish
    Article number0441
    Pages (from-to)A158
    Number of pages1
    JournalSLEEP
    Volume38
    Issue numberAbstract Supplement
    Publication statusPublished - Jun 2015
    Event29th Annual Meeting of the Associated Professional Sleep Societies, LLC - Seattle, United States
    Duration: 6 Jun 201510 Jun 2015

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