Experimental colitis models

Patrick A. Hughes, Stuart M. Brierley, Joel Castro, Andrea M. Harrington, L. Ashley Blackshaw

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)

Abstract

Inflammatory Bowel Diseases (IBD) are life-threatening chronic and relapsing disorders of the immune system affecting the lower gastrointestinal tract. Despite the considerable efforts of many researchers, much remains to be learnt of their causes and appropriate treatment options. Crohn's disease and ulcerative colitis comprise the majority of clinical IBD cases but differ considerably in terms of clinical representation and likely underlying mechanisms. As such, different animal models have been developed over the last 20 years to best characterize these diseases. It is widely accepted that DSS-induced colitis models ulcerative colitis, while TNBS induced colitis models Crohn's disease. More recently, these models have been extended to investigate the mechanisms underlying the reciprocal regulation of the neuro-immune axis, both in times of acute inflammation and post-inflammation, with the latter modeling aspects of Irritable Bowel Syndrome. We describe the methodology involved in setting up, maintenance and evaluation of these two models of colitis, both of which are simply and economically achieved in a standard laboratory environment.

Original languageEnglish
Title of host publicationTRP Channels in Drug Discovery
Subtitle of host publicationVolume II
Editors Arpad Szallasi, Tamas Biro
Place of PublicationTotowa, NJ
PublisherSpringer (Humana Press)
Pages379-390
Number of pages12
ISBN (Electronic)9781627030953
ISBN (Print)9781627030946
DOIs
Publication statusPublished - 2012
Externally publishedYes

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053

Keywords

  • DSS
  • Inflammation
  • Inflammatory Bowel Disease
  • Irritable Bowel Syndrome
  • Sensory nerves
  • TNBS

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