Experimentelle untersuchung der effizienz von silberbeschichteten gefäß-dacronprothesen nach subcutaner implantation im standardisierten in vivo-infektionsmodell

Translated title of the contribution: Experimental examination concerning the efficacy of silver-coated dacron prostheses in vascular graft infections following subcutaneous implantation in a standardized infection model

T. Hernández-Richter, F. Wittmann, S. Mayr, M. Schmitt-Sody, S. Blasenbreu, M. Wichmann, M. M. Heiss, H. M. Schardey, M. K. Angele

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

It was the aim of the study to examine the efficacy of silver coated prostheses in comparison to Rifampin impregnated prostheses in the prevention of vascular graft infections. Material and methods: 24 C3H/HcN mice with a bodyweight between 24 and 27 grams were assigned to four different groups. Group I: control gel-sealed Dacron graft (Uni-Graft®DV) (6), group II: gel-sealed Dacron graft (Uni-Graft®DV) contaminated locally with 2 × 107 CFU/0.2ml Staphylococcus aureus ATCC25923 (6), group III: silver prosthesis (Intergard® Silver) contaminated locally with 2 × 107 CFU/0.2 ml Staphylococcus aureus ATCC 25923 (6), group IV: Rifampin impregnated prosthesis contaminated locally with 2 × 107 CFU/0.2 ml Staphylococcus aureus ATCC 25923 (6). 14 days after primary operation all animals were euthanized and the grafts harvested. Specimens were examined for signs of infections by histology and microbiology. Results: At termination of the trial on day 14 none of the grafts of group 1 were contamined. 6 out of 6 grafts in group 11, 6 out of 6 in group III and 1 out of 6 in group IV presented with infected grafts. The use of the antimicrobial Rifampin could significantly prevent infection after bacterial challenge in group IV. Conclusion: The silver protected prosthesis (Intergard®Silver) seems to be not effective in protecting vascular infection in vivo. However, the Rifampin group showed excellent results. In conclusion Rifampin bonded gelatin-sealed Dacron grafts are significantly more resistant to bacteremic infection than are silver/collagen-coated Dacron grafts.

Translated title of the contributionExperimental examination concerning the efficacy of silver-coated dacron prostheses in vascular graft infections following subcutaneous implantation in a standardized infection model
Original languageGerman
Pages (from-to)244-249
Number of pages6
JournalZentralblatt fur Chirurgie
Volume128
Issue number3
Publication statusPublished - 1 Mar 2003
Externally publishedYes

Keywords

  • Antiseptic agents
  • Silver-coating
  • Standardized infection model
  • Vascular graft infection

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