TY - JOUR
T1 - Expression of a tn-like epitope by carcinoma cells
AU - Roxby, D. J.
AU - Skinner, J. M.
AU - Morley, A. A.
AU - Weeks, S.
AU - Burpee, M.
PY - 1987/12
Y1 - 1987/12
N2 - A monoclonal antibody, FBT3, was raised against Tn positive erythrocytes and, using immunohistochemistry, fresh and fixed tissues from patients with cancer were studied to detect any expression of a Tn-like epitope. Expression was found in neoplastic cells, usually both in cytoplasm and on cell membranes, from 104 of 147 cases of carcinoma and 1 of 13 cases of lymphoma, but rarely in adjacent, morphologically normal cells. Tn expression was seen in some normal glandular cells but, unlike cancer cells, it was distributed as fine granules in a supranuclear position. Detection of a Tn-like epitope is of theoretical interest and may be of direct diagnostic value.
AB - A monoclonal antibody, FBT3, was raised against Tn positive erythrocytes and, using immunohistochemistry, fresh and fixed tissues from patients with cancer were studied to detect any expression of a Tn-like epitope. Expression was found in neoplastic cells, usually both in cytoplasm and on cell membranes, from 104 of 147 cases of carcinoma and 1 of 13 cases of lymphoma, but rarely in adjacent, morphologically normal cells. Tn expression was seen in some normal glandular cells but, unlike cancer cells, it was distributed as fine granules in a supranuclear position. Detection of a Tn-like epitope is of theoretical interest and may be of direct diagnostic value.
UR - http://www.scopus.com/inward/record.url?scp=0023603394&partnerID=8YFLogxK
U2 - 10.1038/bjc.1987.279
DO - 10.1038/bjc.1987.279
M3 - Article
C2 - 2449235
AN - SCOPUS:0023603394
SN - 0007-0920
VL - 56
SP - 734
EP - 737
JO - British Journal of Cancer
JF - British Journal of Cancer
ER -
