Expression of a tn-like epitope by carcinoma cells

D. J. Roxby, J. M. Skinner, A. A. Morley, S. Weeks, M. Burpee

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    A monoclonal antibody, FBT3, was raised against Tn positive erythrocytes and, using immunohistochemistry, fresh and fixed tissues from patients with cancer were studied to detect any expression of a Tn-like epitope. Expression was found in neoplastic cells, usually both in cytoplasm and on cell membranes, from 104 of 147 cases of carcinoma and 1 of 13 cases of lymphoma, but rarely in adjacent, morphologically normal cells. Tn expression was seen in some normal glandular cells but, unlike cancer cells, it was distributed as fine granules in a supranuclear position. Detection of a Tn-like epitope is of theoretical interest and may be of direct diagnostic value.

    Original languageEnglish
    Pages (from-to)734-737
    Number of pages4
    JournalBritish Journal of Cancer
    Volume56
    DOIs
    Publication statusPublished - Dec 1987

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