Expression of a tn-like epitope by carcinoma cells

D. J. Roxby; J. M. Skinner; A. A. Morley; S. Weeks; M. Burpee

doi:10.1038/bjc.1987.279

Expression of a tn-like epitope by carcinoma cells

D. J. Roxby
, J. M. Skinner
, A. A. Morley
, S. Weeks
, M. Burpee

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A monoclonal antibody, FBT3, was raised against Tn positive erythrocytes and, using immunohistochemistry, fresh and fixed tissues from patients with cancer were studied to detect any expression of a Tn-like epitope. Expression was found in neoplastic cells, usually both in cytoplasm and on cell membranes, from 104 of 147 cases of carcinoma and 1 of 13 cases of lymphoma, but rarely in adjacent, morphologically normal cells. Tn expression was seen in some normal glandular cells but, unlike cancer cells, it was distributed as fine granules in a supranuclear position. Detection of a Tn-like epitope is of theoretical interest and may be of direct diagnostic value.

Original language	English
Pages (from-to)	734-737
Number of pages	4
Journal	British Journal of Cancer
Volume	56
DOIs	https://doi.org/10.1038/bjc.1987.279
Publication status	Published - Dec 1987

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title = "Expression of a tn-like epitope by carcinoma cells",

abstract = "A monoclonal antibody, FBT3, was raised against Tn positive erythrocytes and, using immunohistochemistry, fresh and fixed tissues from patients with cancer were studied to detect any expression of a Tn-like epitope. Expression was found in neoplastic cells, usually both in cytoplasm and on cell membranes, from 104 of 147 cases of carcinoma and 1 of 13 cases of lymphoma, but rarely in adjacent, morphologically normal cells. Tn expression was seen in some normal glandular cells but, unlike cancer cells, it was distributed as fine granules in a supranuclear position. Detection of a Tn-like epitope is of theoretical interest and may be of direct diagnostic value.",

author = "Roxby, \{D. J.\} and Skinner, \{J. M.\} and Morley, \{A. A.\} and S. Weeks and M. Burpee",

year = "1987",

month = dec,

doi = "10.1038/bjc.1987.279",

language = "English",

volume = "56",

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T1 - Expression of a tn-like epitope by carcinoma cells

AU - Roxby, D. J.

AU - Skinner, J. M.

AU - Morley, A. A.

AU - Weeks, S.

AU - Burpee, M.

PY - 1987/12

Y1 - 1987/12

N2 - A monoclonal antibody, FBT3, was raised against Tn positive erythrocytes and, using immunohistochemistry, fresh and fixed tissues from patients with cancer were studied to detect any expression of a Tn-like epitope. Expression was found in neoplastic cells, usually both in cytoplasm and on cell membranes, from 104 of 147 cases of carcinoma and 1 of 13 cases of lymphoma, but rarely in adjacent, morphologically normal cells. Tn expression was seen in some normal glandular cells but, unlike cancer cells, it was distributed as fine granules in a supranuclear position. Detection of a Tn-like epitope is of theoretical interest and may be of direct diagnostic value.

AB - A monoclonal antibody, FBT3, was raised against Tn positive erythrocytes and, using immunohistochemistry, fresh and fixed tissues from patients with cancer were studied to detect any expression of a Tn-like epitope. Expression was found in neoplastic cells, usually both in cytoplasm and on cell membranes, from 104 of 147 cases of carcinoma and 1 of 13 cases of lymphoma, but rarely in adjacent, morphologically normal cells. Tn expression was seen in some normal glandular cells but, unlike cancer cells, it was distributed as fine granules in a supranuclear position. Detection of a Tn-like epitope is of theoretical interest and may be of direct diagnostic value.

UR - https://www.scopus.com/pages/publications/0023603394

U2 - 10.1038/bjc.1987.279

DO - 10.1038/bjc.1987.279

M3 - Article

C2 - 2449235

AN - SCOPUS:0023603394

SN - 0007-0920

VL - 56

SP - 734

EP - 737

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

Expression of a tn-like epitope by carcinoma cells

Abstract

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