Extracellular CGMP Reduces the Excitability of Sensory Dorsal Root Ganglion Neurons via an Extracellular Mechanism

Luke A. Grundy, Joel Castro, Andrea Harrington, Stefanie Peters, Robert Feil, Paul Miller, Andre Ghetti, Gerhard Hannig, Caroline Kurtz, Ada Silos-Santiago, Stuart Brierley

    Research output: Contribution to journalMeeting Abstractpeer-review

    Abstract

    Linaclotide, a guanylate cyclase-C (GC-C) agonist, reduces abdominal pain and improves constipation in patients with Irritable Bowel Syndrome with constipation (IBS-C). Cyclic GMP (cGMP) is a second messenger produced in, and released from, intestinal epithelial cells in response to GC-C activation. We have recently shown that both linaclotide and exogenous extracellular cGMP inhibit colonic nociceptor mechanosensitivity with greater efficacy during chronic visceral hypersensitivity (CVH) relative to healthy controls. However, the effects of linaclotide and exogenous cGMP on isolated sensory dorsal root ganglion (DRG) neuron excitability remain to be determined.
    Original languageEnglish
    Pages (from-to)S-156
    Number of pages1
    JournalGastroenterology
    Volume152
    Issue number5, Supplement 1
    DOIs
    Publication statusPublished - Apr 2017
    EventDigestive Disease Week (DDW2017) - McCormick Place, Chicago, United States
    Duration: 6 May 20179 May 2017

    Keywords

    • Linaclotide
    • Guanylate cyclase C
    • sensory dorsal root ganglion
    • IBS-C
    • cGMP
    • DRG
    • dorsal root ganglion
    • CVH
    • Chronic visceral pain

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