Extracellular chaperones

Rebecca A. Dabbs, Amy R. Wyatt, Justin J. Yerbury, Heath Ecroyd, Mark R. Wilson

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

The maintenance of the levels and correct folding state of proteins (proteostasis) is a fundamental prerequisite for life. Life has evolved complex mechanisms to maintain proteostasis and many of these that operate inside cells are now well understood. The same cannot yet be said of corresponding processes in extracellular fluids of the human body, where inappropriate protein aggregation is known to underpin many serious diseases such as Alzheimer's disease, type II diabetes and prion diseases. Recent research has uncovered a growing family of abundant extracellular chaperones in body fluids which appear to selectively bind to exposed regions of hydrophobicity on misfolded proteins to inhibit their toxicity and prevent them from aggregating to form insoluble deposits. These extracellular chaperones are also implicated in clearing the soluble, stabilized misfolded proteins from body fluids via receptor-mediated endocytosis for subsequent lysosomal degradation. Recent work also raises the possibility that extracellular chaperones may play roles in modulating the immune response. Future work will better define the in vivo functions of extracellular chaperones in proteostasis and immunology and pave the way for the development of new treatments for serious diseases.

Original languageEnglish
Title of host publicationMolecular Chaperones
EditorsSophie Jackson
Place of PublicationUnited Kingdom
Chapter6
Pages241-268
Number of pages28
Volume328
ISBN (Electronic)9783642345524
DOIs
Publication statusPublished - 1 Dec 2013

Publication series

NameTOPICS IN CURRENT CHEMISTRY
ISSN (Print)0340-1022

Keywords

  • Clearance
  • Extracellular chaperones
  • Extracellular proteostasis
  • Immune response
  • Protein misfolding diseases
  • Receptor-mediated endocytosis

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  • Cite this

    Dabbs, R. A., Wyatt, A. R., Yerbury, J. J., Ecroyd, H., & Wilson, M. R. (2013). Extracellular chaperones. In S. Jackson (Ed.), Molecular Chaperones (Vol. 328, pp. 241-268). (TOPICS IN CURRENT CHEMISTRY).. https://doi.org/10.1007/128_2011_262