TY - JOUR
T1 - Extracellular vesicles in cancer nanomedicine.
AU - Tarasov, Vadim V.
AU - Svistunov, Andrey A.
AU - Chubarev, Vladimir N.
AU - Dostdar, Samira A.
AU - Sokolov, Alexander V.
AU - Brzecka, Anna
AU - Sukocheva, Olga
AU - Neganova, Margarita E.
AU - Klochkov, Sergey G.
AU - Somasundaram, Siva G.
AU - Kirkland, Cecil E.
AU - Aliev, Gjumrakch
PY - 2021/2
Y1 - 2021/2
N2 - To date, a lot of nanotechnological optitions are available for targeted drug delivery. Extracellular vesicles (EVs) are membrane structures that cells use for storage, transport, communication, and signaling. Recent research has focused on EVs as natural nanoparticles for drug delivery. This review sheds light on the application of EVs in cancer therapy, such as targeted chemotherapy, gene therapy, and vaccine development. Aspects of biogenesis, isolation, targeting, and loading of EVs are discussed in detail.
AB - To date, a lot of nanotechnological optitions are available for targeted drug delivery. Extracellular vesicles (EVs) are membrane structures that cells use for storage, transport, communication, and signaling. Recent research has focused on EVs as natural nanoparticles for drug delivery. This review sheds light on the application of EVs in cancer therapy, such as targeted chemotherapy, gene therapy, and vaccine development. Aspects of biogenesis, isolation, targeting, and loading of EVs are discussed in detail.
KW - Extracellular vesicles
KW - Nanodrug delivery
KW - Vaccines
KW - Exosomes
KW - Cancer
UR - http://www.scopus.com/inward/record.url?scp=85070919844&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2019.08.017
DO - 10.1016/j.semcancer.2019.08.017
M3 - Review article
SN - 1044-579X
VL - 69
SP - 212
EP - 225
JO - SEMINARS IN CANCER BIOLOGY
JF - SEMINARS IN CANCER BIOLOGY
ER -
