Extracellular vesicles in cancer nanomedicine.

Vadim Tarasov; Andrey Svistunov; Vladimir Chubarev; Dostdar SA; Brzecka A; Olga Sukocheva; Margarita Neganova; Sergey Klochkov; Siva Somasundaram; Eric Kirkland; Gjumrakch Aliev

doi:10.1016/j.semcancer.2019.08.017

Extracellular vesicles in cancer nanomedicine.

Vadim Tarasov, Andrey Svistunov, Vladimir Chubarev, Dostdar SA, Brzecka A, Olga Sukocheva, Margarita Neganova, Sergey Klochkov, Siva Somasundaram, Eric Kirkland, Gjumrakch Aliev

College of Nursing and Health Sciences

Research output: Contribution to journal › Review article

11 Citations (Scopus)

Abstract

To date, a lot of nanotechnological optitions are available for targeted drug delivery. Extracellular vesicles (EVs) are membrane structures that cells use for storage, transport, communication, and signaling. Recent research has focused on EVs as natural nanoparticles for drug delivery. This review sheds light on the application of EVs in cancer therapy, such as targeted chemotherapy, gene therapy, and vaccine development. Aspects of biogenesis, isolation, targeting, and loading of EVs are discussed in detail.

Original language	English
Number of pages	14
Journal	SEMINARS IN CANCER BIOLOGY
DOIs	https://doi.org/10.1016/j.semcancer.2019.08.017
Publication status	Accepted/In press - 14 Aug 2019

Keywords

cancer
exosomes
nanodrug delivery
vaccines
extracellular vesicles

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title = "Extracellular vesicles in cancer nanomedicine.",

abstract = "To date, a lot of nanotechnological optitions are available for targeted drug delivery. Extracellular vesicles (EVs) are membrane structures that cells use for storage, transport, communication, and signaling. Recent research has focused on EVs as natural nanoparticles for drug delivery. This review sheds light on the application of EVs in cancer therapy, such as targeted chemotherapy, gene therapy, and vaccine development. Aspects of biogenesis, isolation, targeting, and loading of EVs are discussed in detail.",

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author = "Vadim Tarasov and Andrey Svistunov and Vladimir Chubarev and Dostdar SA and Brzecka A and Olga Sukocheva and Margarita Neganova and Sergey Klochkov and Siva Somasundaram and Eric Kirkland and Gjumrakch Aliev",

year = "2019",

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doi = "10.1016/j.semcancer.2019.08.017",

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T1 - Extracellular vesicles in cancer nanomedicine.

AU - Tarasov, Vadim

AU - Svistunov, Andrey

AU - Chubarev, Vladimir

AU - SA, Dostdar

AU - A, Brzecka

AU - Sukocheva, Olga

AU - Neganova, Margarita

AU - Klochkov, Sergey

AU - Somasundaram, Siva

AU - Kirkland, Eric

AU - Aliev, Gjumrakch

PY - 2019/8/14

Y1 - 2019/8/14

N2 - To date, a lot of nanotechnological optitions are available for targeted drug delivery. Extracellular vesicles (EVs) are membrane structures that cells use for storage, transport, communication, and signaling. Recent research has focused on EVs as natural nanoparticles for drug delivery. This review sheds light on the application of EVs in cancer therapy, such as targeted chemotherapy, gene therapy, and vaccine development. Aspects of biogenesis, isolation, targeting, and loading of EVs are discussed in detail.

AB - To date, a lot of nanotechnological optitions are available for targeted drug delivery. Extracellular vesicles (EVs) are membrane structures that cells use for storage, transport, communication, and signaling. Recent research has focused on EVs as natural nanoparticles for drug delivery. This review sheds light on the application of EVs in cancer therapy, such as targeted chemotherapy, gene therapy, and vaccine development. Aspects of biogenesis, isolation, targeting, and loading of EVs are discussed in detail.

KW - cancer

KW - exosomes

KW - nanodrug delivery

KW - vaccines

KW - extracellular vesicles

U2 - 10.1016/j.semcancer.2019.08.017

DO - 10.1016/j.semcancer.2019.08.017

M3 - Review article

JO - SEMINARS IN CANCER BIOLOGY

JF - SEMINARS IN CANCER BIOLOGY

SN - 1044-579X

ER -