Faecal immunochemical tests for haemoglobin: Analytical challenges and potential solutions

Sally C. Benton, Erin Symonds, Natasha Djedovic, Samantha Jones, Liesbet Deprez, Petr Kocna, Josep Maria Auge

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Quantitative faecal immunochemical tests for haemoglobin (FIT) are being used increasingly around the world in colorectal cancer screening programmes, and in patients presenting with lower bowel symptoms to determine who should proceed to further bowel visualisation investigations, usually colonoscopy. The clinical utility of FIT is well reported. There are a number of analytical challenges including pre-analytical variation, difficulty setting up external quality assessment schemes, access to third party internal quality control material and a lack of standardisation or harmonisation of FIT methods. Here we report the work of the International Federation of Clinical Chemistry FIT Working Group. We provide an overview of the main pre-analytical variables; discuss different approaches to external quality assurance of FIT; propose a solution to third party internal quality assurance materials and summarise the challenges of standardisation and harmonisation of FIT.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalClinica Chimica Acta
Volume517
DOIs
Publication statusPublished - Jun 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021

Keywords

  • Bowel cancer
  • Cancer screening
  • Colorectal cancer
  • External quality assurance
  • Faecal Immunochemical Test
  • FIT
  • Haemoglobin
  • Harmonisation
  • Internal quality assurance
  • Pre-analytical

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