Failure strength of whole human vertebral bodies: prediction using BMD assessed via DXA and micro-architecture via micro-CT

Egon Perilli; Andrew Briggs; John Codrington; John Wark; Sue Kantor; Ian Parkinson; Nick Fazzalari

doi:10.1007/s00198-011-1567-4

Failure strength of whole human vertebral bodies: prediction using BMD assessed via DXA and micro-architecture via micro-CT

Egon Perilli, Andrew Briggs, John Codrington, John Wark, Sue Kantor, Ian Parkinson, Nick Fazzalari

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Significant relationships exist between areal bone mineral density (aBMD) derived from DXA and bone strength. Despite this, the predictive validity of a BMD for osteoporotic vertebral fractures remains suboptimal. Clinically, a BMD of the spine is assessed from posterior-anterior (PA) projections; the diagnostic sensitivity of DXA in the lumbar spine may be improved by assessing a BMD from lateral projections. Nowadays, X-ray microcomputed tomography (μCT) allows 3D structural characterization of entire bone segments, non destructively and at high resolution. The aim of this study was to assess a BMD by lateral-projection DXA and bone volume (BV) by μCT, and to assess their respective capability to predict whole vertebral body strength deter-mined experimentally.

Original language	English
Pages (from-to)	S175-S175
Number of pages	1
Journal	Osteoporosis International
Volume	22
Issue number	Supplement
DOIs	https://doi.org/10.1007/s00198-011-1567-4
Publication status	Published - Mar 2011
Externally published	Yes
Event	European Congress on Osteoporosis and Osteoarthritis (ECCEO11-IOF) - Valencia, Spain Duration: 23 Mar 2011 → 26 Mar 2011

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title = "Failure strength of whole human vertebral bodies: prediction using BMD assessed via DXA and micro-architecture via micro-CT",

abstract = "Significant relationships exist between areal bone mineral density (aBMD) derived from DXA and bone strength. Despite this, the predictive validity of a BMD for osteoporotic vertebral fractures remains suboptimal. Clinically, a BMD of the spine is assessed from posterior-anterior (PA) projections; the diagnostic sensitivity of DXA in the lumbar spine may be improved by assessing a BMD from lateral projections. Nowadays, X-ray microcomputed tomography (μCT) allows 3D structural characterization of entire bone segments, non destructively and at high resolution. The aim of this study was to assess a BMD by lateral-projection DXA and bone volume (BV) by μCT, and to assess their respective capability to predict whole vertebral body strength deter-mined experimentally.",

author = "Egon Perilli and Andrew Briggs and John Codrington and John Wark and Sue Kantor and Ian Parkinson and Nick Fazzalari",

year = "2011",

month = mar,

doi = "10.1007/s00198-011-1567-4",

language = "English",

volume = "22",

pages = "S175--S175",

journal = "Osteoporosis International",

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note = "European Congress on Osteoporosis and Osteoarthritis (ECCEO11-IOF) ; Conference date: 23-03-2011 Through 26-03-2011",

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TY - JOUR

T1 - Failure strength of whole human vertebral bodies

T2 - European Congress on Osteoporosis and Osteoarthritis (ECCEO11-IOF)

AU - Perilli, Egon

AU - Briggs, Andrew

AU - Codrington, John

AU - Wark, John

AU - Kantor, Sue

AU - Parkinson, Ian

AU - Fazzalari, Nick

PY - 2011/3

Y1 - 2011/3

N2 - Significant relationships exist between areal bone mineral density (aBMD) derived from DXA and bone strength. Despite this, the predictive validity of a BMD for osteoporotic vertebral fractures remains suboptimal. Clinically, a BMD of the spine is assessed from posterior-anterior (PA) projections; the diagnostic sensitivity of DXA in the lumbar spine may be improved by assessing a BMD from lateral projections. Nowadays, X-ray microcomputed tomography (μCT) allows 3D structural characterization of entire bone segments, non destructively and at high resolution. The aim of this study was to assess a BMD by lateral-projection DXA and bone volume (BV) by μCT, and to assess their respective capability to predict whole vertebral body strength deter-mined experimentally.

AB - Significant relationships exist between areal bone mineral density (aBMD) derived from DXA and bone strength. Despite this, the predictive validity of a BMD for osteoporotic vertebral fractures remains suboptimal. Clinically, a BMD of the spine is assessed from posterior-anterior (PA) projections; the diagnostic sensitivity of DXA in the lumbar spine may be improved by assessing a BMD from lateral projections. Nowadays, X-ray microcomputed tomography (μCT) allows 3D structural characterization of entire bone segments, non destructively and at high resolution. The aim of this study was to assess a BMD by lateral-projection DXA and bone volume (BV) by μCT, and to assess their respective capability to predict whole vertebral body strength deter-mined experimentally.

U2 - 10.1007/s00198-011-1567-4

DO - 10.1007/s00198-011-1567-4

M3 - Meeting Abstract

SN - 0937-941X

VL - 22

SP - S175-S175

JO - Osteoporosis International

JF - Osteoporosis International

IS - Supplement

Y2 - 23 March 2011 through 26 March 2011

ER -

Failure strength of whole human vertebral bodies: prediction using BMD assessed via DXA and micro-architecture via micro-CT

Abstract

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