Failure strength of whole human vertebral bodies: prediction using BMD assessed via DXA and micro-architecture via micro-CT

Egon Perilli, Andrew Briggs, John Codrington, John Wark, Sue Kantor, Ian Parkinson, Nick Fazzalari

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Significant relationships exist between areal bone mineral density (aBMD) derived from DXA and bone strength. Despite this, the predictive validity of a BMD for osteoporotic vertebral fractures remains suboptimal. Clinically, a BMD of the spine is assessed from posterior-anterior (PA) projections; the diagnostic sensitivity of DXA in the lumbar spine may be improved by assessing a BMD from lateral projections. Nowadays, X-ray microcomputed tomography (μCT) allows 3D structural characterization of entire bone segments, non destructively and at high resolution. The aim of this study was to assess a BMD by lateral-projection DXA and bone volume (BV) by μCT, and to assess their respective capability to predict whole vertebral body strength deter-mined experimentally.
Original languageEnglish
Pages (from-to)S175-S175
Number of pages1
JournalOsteoporosis International
Volume22
Issue numberSupplement
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes
EventEuropean Congress on Osteoporosis and Osteoarthritis (ECCEO11-IOF) - Valencia, Spain
Duration: 23 Mar 201126 Mar 2011

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