Abstract
To the Editor:
Kidney failure treated by replacement therapy has detrimental effects on male sexual hormones, sperm quality and production, and fertility. These changes start in early chronic kidney disease and are incompletely restored posttransplantation. Very little is known about pregnancies fathered by males receiving dialysis, with more data available for kidney transplant recipients. Recently, attention has been drawn to uncertainties regarding the effects of mycophenolic acid (MPA) derivatives on male reproduction, with changes to regulatory and pharmaceutical company recommendations, despite reports of good outcomes for children fathered by males receiving this class of drug and no reports of detrimental effect.
In this context, we retrospectively reviewed parenthood data for males receiving kidney replacement therapy (KRT) from January 1, 1970, to December 31, 2016, reported to the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. Parenthood events with estimated conception date occurring after KRT commencement were classified depending on treatment modality at conception. Detailed methods are provided in Item S1...
Kidney failure treated by replacement therapy has detrimental effects on male sexual hormones, sperm quality and production, and fertility. These changes start in early chronic kidney disease and are incompletely restored posttransplantation. Very little is known about pregnancies fathered by males receiving dialysis, with more data available for kidney transplant recipients. Recently, attention has been drawn to uncertainties regarding the effects of mycophenolic acid (MPA) derivatives on male reproduction, with changes to regulatory and pharmaceutical company recommendations, despite reports of good outcomes for children fathered by males receiving this class of drug and no reports of detrimental effect.
In this context, we retrospectively reviewed parenthood data for males receiving kidney replacement therapy (KRT) from January 1, 1970, to December 31, 2016, reported to the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. Parenthood events with estimated conception date occurring after KRT commencement were classified depending on treatment modality at conception. Detailed methods are provided in Item S1...
| Original language | English |
|---|---|
| Pages (from-to) | 444-446 |
| Number of pages | 3 |
| Journal | American Journal of Kidney Diseases |
| Volume | 76 |
| Issue number | 3 |
| Early online date | 28 May 2020 |
| DOIs | |
| Publication status | Published - Sept 2020 |
| Externally published | Yes |
Keywords
- Kidney disease
- Dialysis
- Males
- Fertility