Feasibility of conducting cardiovascular outcome research in Australian general practice: Results from the ANBP2 pilot study

C. M. Reid, M. Nelson, P. Beckinsale, P. Ryan, L. M.H. Wing, L. J. Beilin, M. A. Brown, G. L.R. Jennings, C. I. Johnston, J Marley, J J McNeil, T. O. Morgan, J. Shaw, I. D. Steven, M. J. West

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5 Citations (Scopus)


1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow- up. Patient records were reviewed to identify subjects for a blood pressure (BP) screening programme. Blood pressure was measured on three occasions and eligible subjects were included if the average BP was ≤ 160 mmHg systolic or ≤ 90 mmHg diastolic if systolic BP was ≤ 140 mmHg. 3. Seven hundred and forty-one GPs were approached and 89 were enrolled in the study (12% of mail invites and 75% of those receiving a personal contact). In 16 practices where screening was completed, 82 000 records were reviewed to identify 4% patients eligible for screening. Twenty-two per cent of eligible subjects attended screening. Of 1938 subjects screened, 180 (9%) had BP ≤ 160/90 mmHg. Forty- seven per cent of subjects (n = 916) were receiving antihypertensive therapy and 184 (20%) were withdrawn from therapy. One hundred and sixteen (63%) of these subjects had BP return to study entry levels within 6 weeks. Fifty- seven newly diagnosed and 81 previously treated subjects were randomized (7% of the screened population). 4. Based on the high participation rate of GPs, the response rate of patients to attend a BP screening programme and the 7% randomization to screening ratio for entry into the study, the ANBP2 pilot study has demonstrated that it is feasible to recruit subjects from Australian general practices to a cardiovascular outcome trial.

Original languageEnglish
Pages (from-to)370-373
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Issue number5
Publication statusPublished - 1 Jan 1997
Externally publishedYes


  • cardiovascular outcome
  • elderly
  • general practice
  • hypertension
  • pilot study


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