Fecal microbiota transplant for clostridium difficile colitis-induced toxic megacolon

S. P. Costello, A. Chung, J. M. Andrews, R. J. Fraser

    Research output: Contribution to journalLetter

    17 Citations (Scopus)

    Abstract

    To the Editor: Toxic megacolon (TMC) is a severe and potentially fatal complication of colonic inflammation in which acute colonic distension >6 cm is accompanied by major systemic disturbance (1). It occurs as a complication in up to 5% of cases of Clostridium difficile (CD)-induced colitis (2, 3, 4). The standard treatment for TMC is subtotal colectomy (5). Here we report the first case of fecal microbiota transplant (FMT) as an effective treatment for TMC without surgery.
    Original languageEnglish
    Pages (from-to)775-777
    Number of pages3
    JournalAmerican Journal of Gastroenterology
    Volume110
    Issue number5
    DOIs
    Publication statusPublished - May 2015

    Keywords

    • Fecal Microbiota Transplant
    • Toxic megacolon (TMC)
    • acute colonic distension

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