Fecal microbiota transplant for clostridium difficile colitis-induced toxic megacolon

S. P. Costello; A. Chung; J. M. Andrews; R. J. Fraser

doi:10.1038/ajg.2015.70

Fecal microbiota transplant for clostridium difficile colitis-induced toxic megacolon

S. P. Costello, A. Chung, J. M. Andrews, R. J. Fraser

Research output: Contribution to journal › Letter › peer-review

22 Citations (Scopus)

Abstract

To the Editor: Toxic megacolon (TMC) is a severe and potentially fatal complication of colonic inflammation in which acute colonic distension >6 cm is accompanied by major systemic disturbance (1). It occurs as a complication in up to 5% of cases of Clostridium difficile (CD)-induced colitis (2, 3, 4). The standard treatment for TMC is subtotal colectomy (5). Here we report the first case of fecal microbiota transplant (FMT) as an effective treatment for TMC without surgery.

Original language	English
Pages (from-to)	775-777
Number of pages	3
Journal	The American Journal of Gastroenterology
Volume	110
Issue number	5
DOIs	https://doi.org/10.1038/ajg.2015.70
Publication status	Published - May 2015

Keywords

Fecal Microbiota Transplant
Toxic megacolon (TMC)
acute colonic distension

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title = "Fecal microbiota transplant for clostridium difficile colitis-induced toxic megacolon",

abstract = "To the Editor: Toxic megacolon (TMC) is a severe and potentially fatal complication of colonic inflammation in which acute colonic distension >6 cm is accompanied by major systemic disturbance (1). It occurs as a complication in up to 5% of cases of Clostridium difficile (CD)-induced colitis (2, 3, 4). The standard treatment for TMC is subtotal colectomy (5). Here we report the first case of fecal microbiota transplant (FMT) as an effective treatment for TMC without surgery.",

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AU - Andrews, J. M.

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N2 - To the Editor: Toxic megacolon (TMC) is a severe and potentially fatal complication of colonic inflammation in which acute colonic distension >6 cm is accompanied by major systemic disturbance (1). It occurs as a complication in up to 5% of cases of Clostridium difficile (CD)-induced colitis (2, 3, 4). The standard treatment for TMC is subtotal colectomy (5). Here we report the first case of fecal microbiota transplant (FMT) as an effective treatment for TMC without surgery.

AB - To the Editor: Toxic megacolon (TMC) is a severe and potentially fatal complication of colonic inflammation in which acute colonic distension >6 cm is accompanied by major systemic disturbance (1). It occurs as a complication in up to 5% of cases of Clostridium difficile (CD)-induced colitis (2, 3, 4). The standard treatment for TMC is subtotal colectomy (5). Here we report the first case of fecal microbiota transplant (FMT) as an effective treatment for TMC without surgery.

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Fecal microbiota transplant for clostridium difficile colitis-induced toxic megacolon

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Keywords

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