To the Editor: Toxic megacolon (TMC) is a severe and potentially fatal complication of colonic inflammation in which acute colonic distension >6 cm is accompanied by major systemic disturbance (1). It occurs as a complication in up to 5% of cases of Clostridium difficile (CD)-induced colitis (2, 3, 4). The standard treatment for TMC is subtotal colectomy (5). Here we report the first case of fecal microbiota transplant (FMT) as an effective treatment for TMC without surgery.
- Fecal Microbiota Transplant
- Toxic megacolon (TMC)
- acute colonic distension
Costello, S. P., Chung, A., Andrews, J. M., & Fraser, R. J. (2015). Fecal microbiota transplant for clostridium difficile colitis-induced toxic megacolon. American Journal of Gastroenterology, 110(5), 775-777. https://doi.org/10.1038/ajg.2015.70