Fibre intake is independently associated with increased circulating interleukin-22 in individuals with metabolic syndrome

Luciana Torquati, Jeff S. Coombes, Lydia Murray, Sumaira Z. Hasnain, Alistair R. Mallard, Michael A. McGuckin, Robert G. Fassett, Ilaria Croci, Joyce S. Ramos

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    The positive effects of dietary fibre on gut barrier function and inflammation have not been completely elucidated. Mice studies show gut barrier disruption and diet-induced insulin resistance can be alleviated by cytokine interleukin-22 (IL-22). However, little is known about IL-22 in humans and its association with gut-beneficial nutrients like fibre. We investigated whether fibre intake was associated with circulating levels of IL-22 in 48 participants with metabolic syndrome (MetS). Bivariate analysis was used to explore associations between circulating IL-22, fibre intake, MetS factors, body composition, and cardiorespiratory fitness (peak oxygen uptake, V˙ O2peak). Hierarchical multiple regression (HMR) was used to test the independent association of fibre intake with circulating IL-22, adjusting for variables correlated with IL-22. Circulating IL-22 was positively associated with fibre intake (rs = 0.393, p < 0.006). The HMR-adjusted model explained 40% of circulating IL-22 variability, and fibre intake significantly improved the prediction model by 8.4% (p < 0.022). Participants with fibre intake above median intake of 21.5 g/day had a significantly higher circulating IL-22 than the lower intake group (308.3 ± 454.4 vs. 69.0 ± 106.4 pg/mL, p < 0.019). Fibre intake is independently associated with increased circulating IL-22 in individuals with MetS. Findings warrant further investigations to evaluate whether changes in dietary fibre intake alter circulating IL-22, and its effects on health outcomes.

    Original languageEnglish
    Article number815
    Number of pages11
    JournalNutrients
    Volume11
    Issue number4
    DOIs
    Publication statusPublished - 11 Apr 2019

    Bibliographical note

    This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

    Keywords

    • Dietary fibre
    • Immune response
    • Metabolic endotoxemia

    Fingerprint Dive into the research topics of 'Fibre intake is independently associated with increased circulating interleukin-22 in individuals with metabolic syndrome'. Together they form a unique fingerprint.

  • Cite this

    Torquati, L., Coombes, J. S., Murray, L., Hasnain, S. Z., Mallard, A. R., McGuckin, M. A., Fassett, R. G., Croci, I., & Ramos, J. S. (2019). Fibre intake is independently associated with increased circulating interleukin-22 in individuals with metabolic syndrome. Nutrients, 11(4), [815]. https://doi.org/10.3390/nu11040815