Fibre intake is independently associated with increased circulating interleukin-22 in individuals with metabolic syndrome

Luciana Torquati, Jeff S. Coombes, Lydia Murray, Sumaira Z. Hasnain, Alistair R. Mallard, Michael A. McGuckin, Robert G. Fassett, Ilaria Croci, Joyce S. Ramos

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
22 Downloads (Pure)

Abstract

The positive effects of dietary fibre on gut barrier function and inflammation have not been completely elucidated. Mice studies show gut barrier disruption and diet-induced insulin resistance can be alleviated by cytokine interleukin-22 (IL-22). However, little is known about IL-22 in humans and its association with gut-beneficial nutrients like fibre. We investigated whether fibre intake was associated with circulating levels of IL-22 in 48 participants with metabolic syndrome (MetS). Bivariate analysis was used to explore associations between circulating IL-22, fibre intake, MetS factors, body composition, and cardiorespiratory fitness (peak oxygen uptake, V˙ O2peak). Hierarchical multiple regression (HMR) was used to test the independent association of fibre intake with circulating IL-22, adjusting for variables correlated with IL-22. Circulating IL-22 was positively associated with fibre intake (rs = 0.393, p < 0.006). The HMR-adjusted model explained 40% of circulating IL-22 variability, and fibre intake significantly improved the prediction model by 8.4% (p < 0.022). Participants with fibre intake above median intake of 21.5 g/day had a significantly higher circulating IL-22 than the lower intake group (308.3 ± 454.4 vs. 69.0 ± 106.4 pg/mL, p < 0.019). Fibre intake is independently associated with increased circulating IL-22 in individuals with MetS. Findings warrant further investigations to evaluate whether changes in dietary fibre intake alter circulating IL-22, and its effects on health outcomes.

Original languageEnglish
Article number815
Number of pages11
JournalNutrients
Volume11
Issue number4
DOIs
Publication statusPublished - 11 Apr 2019

Bibliographical note

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

  • Dietary fibre
  • Immune response
  • Metabolic endotoxemia

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