Filterability of human serum albumin in parenteral nutrition administered to neonates through an in-line 0.2 micron filter

The use of albumin infusions in neonates remains controversial. Hypoalbuminaemia is associated with necrotising enterocolitis and lung disease; however, correction of low serum albumin does not demonstrably improve neonatal morbidity or mortality.1 Despite this, albumin is widely used in neonatal intensive care. Although commonly used, there is no clear guidance as to the most appropriate method of administration.