First steps towards harmonisation of serum total bile acids

Corey Markus

Abstract

The synthesis of bile acids (BAs) from cholesterol is a complex, multi-step process which occurs predominantly in hepatocytes. Disturbances in the BA cycles result in an accumulation of different BA species, which can have cytotoxic effects at increased concentrations. Intrahepatic Cholestasis of Pregnancy (ICP) is a rare disorder associated with an increased risk of stillbirth, premature birth, and foetal compromise, as well as causing maternal distress from severe pruritus.

Original language	English
Pages (from-to)	S12
Number of pages	1
Journal	Clinical Biochemist Reviews
Volume	40
Issue number	4
Publication status	Published - 1 Jan 2020
Externally published	Yes
Event	Australasian Association of Clinical Biochemists 57th Annual Scientific Conference - Adelaide, Australia Duration: 15 Oct 2019 → 17 Oct 2019 Conference number: 57th

Keywords

harmonisation
serum
total bile acids
bile acids
hepatocytes
BA cycles

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title = "First steps towards harmonisation of serum total bile acids",

abstract = "The synthesis of bile acids (BAs) from cholesterol is a complex, multi-step process which occurs predominantly in hepatocytes. Disturbances in the BA cycles result in an accumulation of different BA species, which can have cytotoxic effects at increased concentrations. Intrahepatic Cholestasis of Pregnancy (ICP) is a rare disorder associated with an increased risk of stillbirth, premature birth, and foetal compromise, as well as causing maternal distress from severe pruritus.",

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AB - The synthesis of bile acids (BAs) from cholesterol is a complex, multi-step process which occurs predominantly in hepatocytes. Disturbances in the BA cycles result in an accumulation of different BA species, which can have cytotoxic effects at increased concentrations. Intrahepatic Cholestasis of Pregnancy (ICP) is a rare disorder associated with an increased risk of stillbirth, premature birth, and foetal compromise, as well as causing maternal distress from severe pruritus.

KW - harmonisation

KW - serum

KW - total bile acids

KW - bile acids

KW - hepatocytes

KW - BA cycles

M3 - Meeting Abstract

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JO - Clinical Biochemist Reviews

JF - Clinical Biochemist Reviews

IS - 4

T2 - Australasian Association of Clinical Biochemists 57th Annual Scientific Conference

Y2 - 15 October 2019 through 17 October 2019

ER -

First steps towards harmonisation of serum total bile acids

Abstract

Keywords

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