Floating and sustained-release characteristics of effervescent tablets prepared with a mixed matrix of eudragit L-100-55 and eudragit E PO

Ahmad Khaled Bani-Jaber, Mahmoud Yousef Alkawareek, Jozef Jawad Al-Gousous, Ahmad Yousef Abu Helwa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The aim of this study was to evaluate the influence of Na-bicarbonate as an effervescent agent on the floating and sustained-release characteristics in 0.1 M HCl of tablets made of Eudragit E PO (EE) and/or Eudragit L-100-55 (EL) as matrix formers at different EE : EL weight ratios: 0 : 100, 25 : 75, 50 : 50, 75 : 25, and 100 : 0. The tablets were made by direct compression utilizing metronidazole as a model drug. Effervescent tablets with 50EE/50EL (w/w) showed the best floating and sustained drug release properties in the dissolution medium. The corresponding noneffervescent tablets were nonfloating and showed significantly faster drug release. Effervescent tablets with single polymers showed an immediate drug release pattern. These results were explained by Fourier-transform infrared spectroscopy and elemental analysis, which showed strong evidence of interpolyelectrolyte complexation between EE and EL when they were exposed to 0.1 M HCl as an effervescent hybrid matrix, but not as a noneffervescent hybrid matrix. The role of Na-bicarbonate in allowing EE-EL complexation during dissolution was explained as due to raising the pH around EL particles for sufficient polymer ionization and ionic-interaction with the ionized EE.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume59
Issue number2
DOIs
Publication statusPublished - Feb 2011
Externally publishedYes

Keywords

  • Eudragit E
  • Eudragit L
  • Floating tablet
  • Gastroretentive system
  • Sustained release

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