Flow cytometric monocyte repartition demonstrates overlap between chronic myelomonocytic leukaemia and myeloid neoplasms with monocytosis

Sharon A. Allen; Eugene Ng; Uwe H. Hahn; Tatjana Banovic; David M. Ross

doi:10.1016/j.pathol.2021.12.294

Flow cytometric monocyte repartition demonstrates overlap between chronic myelomonocytic leukaemia and myeloid neoplasms with monocytosis

Sharon A. Allen, Eugene Ng, Uwe H. Hahn, Tatjana Banovic, David M. Ross

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

To the Editor,
Chronic myelomonocytic leukaemia (CMML) is a clonal myeloid malignancy resulting in both myelodysplastic and myeloproliferative features with risk of progression to acute myeloid leukaemia (AML). Current diagnostic criteria for CMML require persistent monocytosis of ≥1.0×109/L with monocytes accounting for ≥10% of leukocytes, <20% blasts in the peripheral blood and bone marrow, and either dysplasia involving ≥1 myeloid lineages or demonstration of an acquired, clonal cytogenetic or molecular abnormality. Challenges remain in the diagnosis of CMML given the subjective nature of dysplasia and lack of a definitive cytogenetic or molecular abnormality.

The CMML diagnostic criteria of the World Health Organization do not include specific immunophenotypic results...

Original language	English
Pages (from-to)	953-955
Number of pages	3
Journal	Pathology
Volume	54
Issue number	7
Early online date	15 Mar 2022
DOIs	https://doi.org/10.1016/j.pathol.2021.12.294
Publication status	Published - Dec 2022
Externally published	Yes

Keywords

Chronic myelomonocytic leukaemia (CMML)
myeloid malignancy
monocytosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pathol.2021.12.294Licence: In Copyright

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title = "Flow cytometric monocyte repartition demonstrates overlap between chronic myelomonocytic leukaemia and myeloid neoplasms with monocytosis",

abstract = "To the Editor,Chronic myelomonocytic leukaemia (CMML) is a clonal myeloid malignancy resulting in both myelodysplastic and myeloproliferative features with risk of progression to acute myeloid leukaemia (AML). Current diagnostic criteria for CMML require persistent monocytosis of ≥1.0×109/L with monocytes accounting for ≥10% of leukocytes, <20% blasts in the peripheral blood and bone marrow, and either dysplasia involving ≥1 myeloid lineages or demonstration of an acquired, clonal cytogenetic or molecular abnormality. Challenges remain in the diagnosis of CMML given the subjective nature of dysplasia and lack of a definitive cytogenetic or molecular abnormality.The CMML diagnostic criteria of the World Health Organization do not include specific immunophenotypic results...",

keywords = "Chronic myelomonocytic leukaemia (CMML), myeloid malignancy, monocytosis",

author = "Allen, {Sharon A.} and Eugene Ng and Hahn, {Uwe H.} and Tatjana Banovic and Ross, {David M.}",

year = "2022",

month = dec,

doi = "10.1016/j.pathol.2021.12.294",

language = "English",

volume = "54",

pages = "953--955",

journal = "Pathology",

issn = "0031-3025",

publisher = "Elsevier Ltd.",

number = "7",

}

TY - JOUR

T1 - Flow cytometric monocyte repartition demonstrates overlap between chronic myelomonocytic leukaemia and myeloid neoplasms with monocytosis

AU - Allen, Sharon A.

AU - Ng, Eugene

AU - Hahn, Uwe H.

AU - Banovic, Tatjana

AU - Ross, David M.

PY - 2022/12

Y1 - 2022/12

N2 - To the Editor,Chronic myelomonocytic leukaemia (CMML) is a clonal myeloid malignancy resulting in both myelodysplastic and myeloproliferative features with risk of progression to acute myeloid leukaemia (AML). Current diagnostic criteria for CMML require persistent monocytosis of ≥1.0×109/L with monocytes accounting for ≥10% of leukocytes, <20% blasts in the peripheral blood and bone marrow, and either dysplasia involving ≥1 myeloid lineages or demonstration of an acquired, clonal cytogenetic or molecular abnormality. Challenges remain in the diagnosis of CMML given the subjective nature of dysplasia and lack of a definitive cytogenetic or molecular abnormality.The CMML diagnostic criteria of the World Health Organization do not include specific immunophenotypic results...

AB - To the Editor,Chronic myelomonocytic leukaemia (CMML) is a clonal myeloid malignancy resulting in both myelodysplastic and myeloproliferative features with risk of progression to acute myeloid leukaemia (AML). Current diagnostic criteria for CMML require persistent monocytosis of ≥1.0×109/L with monocytes accounting for ≥10% of leukocytes, <20% blasts in the peripheral blood and bone marrow, and either dysplasia involving ≥1 myeloid lineages or demonstration of an acquired, clonal cytogenetic or molecular abnormality. Challenges remain in the diagnosis of CMML given the subjective nature of dysplasia and lack of a definitive cytogenetic or molecular abnormality.The CMML diagnostic criteria of the World Health Organization do not include specific immunophenotypic results...

KW - Chronic myelomonocytic leukaemia (CMML)

KW - myeloid malignancy

KW - monocytosis

UR - http://www.scopus.com/inward/record.url?scp=85142918976&partnerID=8YFLogxK

U2 - 10.1016/j.pathol.2021.12.294

DO - 10.1016/j.pathol.2021.12.294

M3 - Letter

C2 - 35304012

AN - SCOPUS:85142918976

SN - 0031-3025

VL - 54

SP - 953

EP - 955

JO - Pathology

JF - Pathology

IS - 7

ER -

Flow cytometric monocyte repartition demonstrates overlap between chronic myelomonocytic leukaemia and myeloid neoplasms with monocytosis

Abstract

Keywords

UN SDGs

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