Fluctuating selection and the determinants of genetic variation

Olivia L. Johnson, Raymond Tobler, Joshua M. Schmidt, Christian D. Huber

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)
15 Downloads (Pure)

Abstract

Recent studies of cosmopolitan Drosophila populations have found hundreds to thousands of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating selection to the forefront of the historical debate surrounding the maintenance of genetic variation in natural populations. Numerous mechanisms have been explored in this longstanding area of research, but these exciting empirical findings have prompted several recent theoretical and experimental studies that seek to better understand the drivers, dynamics, and genome-wide influence of fluctuating selection. In this review, we evaluate the latest evidence for multilocus fluctuating selection in Drosophila and other taxa, highlighting the role of potential genetic and ecological mechanisms in maintaining these loci and their impacts on neutral genetic variation.
Original languageEnglish
Pages (from-to)491-504
Number of pages14
JournalTrends in Genetics
Volume39
Issue number6
Early online date6 Mar 2023
DOIs
Publication statusE-pub ahead of print - 6 Mar 2023

Keywords

  • fluctuating selection
  • genetic variation
  • balancing selection
  • dominance reversal

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