Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment

Babak Rad, Mohamed Saleem, Susan Grant, Christopher Florkowski, Penelope Coates, David Gordon, Wayne Rankin

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


We describe a case of development of painful periostitis deformans in a 39-year-old woman who was receiving long-term voriconazole treatment for Aspergillus infection as a complication of orthotopic liver transplant. Measurement of fluoride levels strongly supports fluorosis to be the mechanism of the voriconazole-induced periostitis deformans and supports the concept that such measurements might be of use in predicting this complication of long-term voriconazole treatment.

Original languageEnglish
Pages (from-to)611-614
Number of pages4
JournalAnnals of Clinical Biochemistry
Issue number5
Publication statusPublished - 1 Sep 2015
Externally publishedYes


  • bone disorders
  • clinical studies
  • L Drugs analytes


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