Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment

Babak Rad; Mohamed Saleem; Susan Grant; Christopher Florkowski; Penelope Coates; David Gordon; Wayne Rankin

doi:10.1177/0004563214568873

Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment

Babak Rad, Mohamed Saleem, Susan Grant, Christopher Florkowski, Penelope Coates, David Gordon, Wayne Rankin

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We describe a case of development of painful periostitis deformans in a 39-year-old woman who was receiving long-term voriconazole treatment for Aspergillus infection as a complication of orthotopic liver transplant. Measurement of fluoride levels strongly supports fluorosis to be the mechanism of the voriconazole-induced periostitis deformans and supports the concept that such measurements might be of use in predicting this complication of long-term voriconazole treatment.

Original language	English
Pages (from-to)	611-614
Number of pages	4
Journal	Annals of Clinical Biochemistry
Volume	52
Issue number	5
DOIs	https://doi.org/10.1177/0004563214568873
Publication status	Published - 1 Sept 2015
Externally published	Yes

Keywords

bone disorders
clinical studies
L Drugs analytes

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AU - Rad, Babak

AU - Saleem, Mohamed

AU - Grant, Susan

AU - Florkowski, Christopher

AU - Coates, Penelope

AU - Gordon, David

AU - Rankin, Wayne

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AB - We describe a case of development of painful periostitis deformans in a 39-year-old woman who was receiving long-term voriconazole treatment for Aspergillus infection as a complication of orthotopic liver transplant. Measurement of fluoride levels strongly supports fluorosis to be the mechanism of the voriconazole-induced periostitis deformans and supports the concept that such measurements might be of use in predicting this complication of long-term voriconazole treatment.

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ER -

Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment

Abstract

Keywords

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