Fluvoxamine-methadone interaction

Christopher P. Alderman, Peter A. Frith

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Objective: The aim of this paper is to report a case of symptomatic methadone toxicity associated with fluvoxamine treatment. Clinical picture: A 28-year-old woman was admitted to hospital with severe hyperaemia and hypercapnia indicating hypoventilation. Medication prior to admission had been stable and included methadone 70 mg daily and diazepam 2 mg twice daily. Three weeks before admission she had commenced treatment with fluvoxamine. Treatment: Methadone was decreased to 50 mg daily and diazepam was tapered to zero. Outcome: The serum methadone concentration decreased and oxygenation improved considerably. Conclusions: Clinicians should be aware of the potential for a significant drug interaction between fluvoxamine and methadone.

Original languageEnglish
Pages (from-to)99-101
Number of pages3
JournalAustralian and New Zealand Journal of Psychiatry
Issue number1
Publication statusPublished - 1 Feb 1999
Externally publishedYes


  • Drug interaction
  • Fluvoxamine
  • Methadone


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