Fluvoxamine-methadone interaction

Christopher P. Alderman; Peter A. Frith

doi:10.1046/j.1440-1614.1999.00522.x

Fluvoxamine-methadone interaction

Christopher P. Alderman, Peter A. Frith

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Objective: The aim of this paper is to report a case of symptomatic methadone toxicity associated with fluvoxamine treatment. Clinical picture: A 28-year-old woman was admitted to hospital with severe hyperaemia and hypercapnia indicating hypoventilation. Medication prior to admission had been stable and included methadone 70 mg daily and diazepam 2 mg twice daily. Three weeks before admission she had commenced treatment with fluvoxamine. Treatment: Methadone was decreased to 50 mg daily and diazepam was tapered to zero. Outcome: The serum methadone concentration decreased and oxygenation improved considerably. Conclusions: Clinicians should be aware of the potential for a significant drug interaction between fluvoxamine and methadone.

Original language	English
Pages (from-to)	99-101
Number of pages	3
Journal	Australian and New Zealand Journal of Psychiatry
Volume	33
Issue number	1
DOIs	https://doi.org/10.1046/j.1440-1614.1999.00522.x
Publication status	Published - 1 Feb 1999
Externally published	Yes

Keywords

Drug interaction
Fluvoxamine
Methadone

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10.1046/j.1440-1614.1999.00522.xLicence: In Copyright

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abstract = "Objective: The aim of this paper is to report a case of symptomatic methadone toxicity associated with fluvoxamine treatment. Clinical picture: A 28-year-old woman was admitted to hospital with severe hyperaemia and hypercapnia indicating hypoventilation. Medication prior to admission had been stable and included methadone 70 mg daily and diazepam 2 mg twice daily. Three weeks before admission she had commenced treatment with fluvoxamine. Treatment: Methadone was decreased to 50 mg daily and diazepam was tapered to zero. Outcome: The serum methadone concentration decreased and oxygenation improved considerably. Conclusions: Clinicians should be aware of the potential for a significant drug interaction between fluvoxamine and methadone.",

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AU - Frith, Peter A.

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AB - Objective: The aim of this paper is to report a case of symptomatic methadone toxicity associated with fluvoxamine treatment. Clinical picture: A 28-year-old woman was admitted to hospital with severe hyperaemia and hypercapnia indicating hypoventilation. Medication prior to admission had been stable and included methadone 70 mg daily and diazepam 2 mg twice daily. Three weeks before admission she had commenced treatment with fluvoxamine. Treatment: Methadone was decreased to 50 mg daily and diazepam was tapered to zero. Outcome: The serum methadone concentration decreased and oxygenation improved considerably. Conclusions: Clinicians should be aware of the potential for a significant drug interaction between fluvoxamine and methadone.

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KW - Methadone

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Fluvoxamine-methadone interaction

Abstract

Keywords

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