Folate

Zoe Lofft; Timothy J. Green; Angela M. Devlin

doi:10.1016/j.advnut.2025.100519

Folate

Zoe Lofft, Timothy J. Green, Angela M. Devlin

College of Nursing and Health Sciences

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Abstract

Folates are a group of chemically related compounds that share a common structure comprising 3 moieties: a pteridine ring (in an oxidized or reduced form), para-aminobenzoic acid bridge, and mono- or polyglutamate tail [1]. Broadly, folates can be classified as naturally occurring or synthetic. Food folates are in the reduced form, predominantly tetrahydrofolate (THF), and are polyglutamated, whereas most synthetic folates, such as folic acid, are highly stable, oxidized, and monoglutamated.

Original language	English
Article number	100519
Number of pages	4
Journal	Advances in Nutrition
Volume	16
Issue number	11
DOIs	https://doi.org/10.1016/j.advnut.2025.100519
Publication status	Published - Nov 2025

Keywords

folate
tetrahydrofolate (THF)
polyglutamated
monoglutamated
pH-dependent active transport
natural folates
chemical compounds

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title = "Folate",

abstract = "Folates are a group of chemically related compounds that share a common structure comprising 3 moieties: a pteridine ring (in an oxidized or reduced form), para-aminobenzoic acid bridge, and mono- or polyglutamate tail [1]. Broadly, folates can be classified as naturally occurring or synthetic. Food folates are in the reduced form, predominantly tetrahydrofolate (THF), and are polyglutamated, whereas most synthetic folates, such as folic acid, are highly stable, oxidized, and monoglutamated.",

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AU - Green, Timothy J.

AU - Devlin, Angela M.

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AB - Folates are a group of chemically related compounds that share a common structure comprising 3 moieties: a pteridine ring (in an oxidized or reduced form), para-aminobenzoic acid bridge, and mono- or polyglutamate tail [1]. Broadly, folates can be classified as naturally occurring or synthetic. Food folates are in the reduced form, predominantly tetrahydrofolate (THF), and are polyglutamated, whereas most synthetic folates, such as folic acid, are highly stable, oxidized, and monoglutamated.

KW - folate

KW - tetrahydrofolate (THF)

KW - polyglutamated

KW - monoglutamated

KW - pH-dependent active transport

KW - natural folates

KW - chemical compounds

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JO - Advances in Nutrition

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Folate

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Keywords

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