FRAIL scale: Predictive validity and diagnostic test accuracy

Mark Q. Thompson, Olga Theou, Graeme R. Tucker, Robert J. Adams, Renuka Visvanathan

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Objective: To examine the predictive validity of the FRAIL scale for mortality, and diagnostic test accuracy (DTA) against the frailty phenotype (FP). Measurement: Frailty was measured in 846 community-dwelling adults (mean age 74.3[SD 6.3] years, 54.8% female) using a modified FRAIL scale and modified FP. Mortality was matched to death records. Results: The FRAIL scale demonstrated significant predictive validity for mortality up to 10 years (Frail adjHR: 2.60, P <.001). DTA findings were acceptable for specificity (86.8%) and Youden index (0.50), but not sensitivity (63.6%), or area under the receiver operator curve (auROC) (0.75). DTA estimates were more acceptable when a cut-point of ≥2 characteristics was used rather than ≥3 in the primary DTA analysis. Conclusion: The FRAIL scale is a valid predictor of mortality. DTA estimates depend on FRAIL scale cut-point used. This instrument is a potentially useful frailty screening tool.

Original languageEnglish
Pages (from-to)e529-e536
Number of pages8
JournalAustralasian Journal on Ageing
Issue number4
Early online date4 Aug 2020
Publication statusPublished - Dec 2020


  • Australia
  • frailty
  • mortality
  • screening


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