From blood to breath: New horizons for esophageal cancer biomarkers

Roger Yazbeck, Simone Jaenisch, David Watson

    Research output: Contribution to journalReview articlepeer-review

    24 Citations (Scopus)
    27 Downloads (Pure)


    Esophageal cancer is a lethal cancer encompassing adenocarcinoma and squamous cell carcinoma subtypes. The global incidence of esophageal cancer is increasing world-wide, associated with the increased prevalence of associated risk factors. The asymptomatic nature of disease often leads to late diagnosis and five-year survival rates of less than 15%. Current diagnostic tools are restricted to invasive and costly endoscopy and biopsy for histopathology. Minimally and non-invasive biomarkers of esophageal cancer are needed to facilitate earlier detection and better clinical management of patients. This paper summarises recent insights into the development and clinical validation of esophageal cancer biomarkers, focussing on circulating markers in the blood, and the emerging area of breath and odorant biomarkers.

    Original languageEnglish
    Pages (from-to)10077-10083
    Number of pages7
    JournalWorld Journal of Gastroenterology
    Issue number46
    Publication statusPublished - 14 Dec 2016

    Bibliographical note

    Distributed under the terms of the Creative Commons Attribution-Noncommercial (CC BY-NC 4.0) License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.


    • Breath analysis
    • Cancer
    • MicroRNA
    • Noninvasive
    • Esophageal cancer
    • Biomarker
    • Non-invasive


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