Frontal variant of Alzheimer’s disease masquerading as behavioural-variant frontotemporal dementia: a case study comparison

Stephanie Wong, Jessica Strudwick, Emma Devenney, John R. Hodges, Olivier Piguet, Fiona Kumfor

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The current clinical diagnostic criteria for Alzheimer’s disease (AD) recognize an atypical, non-amnestic presentation of AD, characterized by prominent executive dysfunction. Increasing evidence, however, indicates that the clinical phenotype of this so-called “frontal-variant” of AD (fv-AD) includes behavioral symptoms and deficits in social cognition, together with disproportionate frontal lobe atrophy. As these features resemble those characteristic of behavioral-variant frontotemporal dementia (bvFTD), differential diagnosis can be challenging. Here, we report a case of fv-AD who met clinical diagnostic criteria bvFTD, but had in vivo amyloid neuroimaging evidence of AD pathology. We compare this case against two individuals who were clinically diagnosed with bvFTD and early-onset AD, with in vivo amyloid neuroimaging confirmation of pathology. We highlight the challenges in differential diagnosis by contrasting their behavioral, cognitive and structural neuroimaging findings.

Original languageEnglish
Pages (from-to)48-58
Number of pages11
JournalNeurocase
Volume25
Issue number1-2
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • behavioural-variant frontotemporal dementia
  • episodic memory
  • executive function
  • social cognition

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