Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

Geraint Rogers, Justyna Kozlowska, Julie Keeble, K Metcalfe, M Fao, Scot Dowd, A. Mason, Michael McGuckin, Kenneth Bruce

    Research output: Contribution to journalArticlepeer-review

    38 Citations (Scopus)

    Abstract

    Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

    Original languageEnglish
    Article number5437
    JournalScientific Reports
    Volume4
    Issue numberArt. No.: 5437
    DOIs
    Publication statusPublished - 25 Jun 2014

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