Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

Geraint Rogers, Justyna Kozlowska, Julie Keeble, K Metcalfe, M Fao, Scot Dowd, A. Mason, Michael McGuckin, Kenneth Bruce

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    34 Citations (Scopus)

    Abstract

    Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

    Original languageEnglish
    Article number5437
    JournalScientific Reports
    Volume4
    Issue numberArt. No.: 5437
    DOIs
    Publication statusPublished - 2014

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  • Cite this

    Rogers, G., Kozlowska, J., Keeble, J., Metcalfe, K., Fao, M., Dowd, S., Mason, A., McGuckin, M., & Bruce, K. (2014). Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice. Scientific Reports, 4(Art. No.: 5437), [5437]. https://doi.org/10.1038/srep05437