Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

Geraint Rogers; Justyna Kozlowska; Julie Keeble; K Metcalfe; M Fao; Scot Dowd; A. Mason; Michael McGuckin; Kenneth Bruce

doi:10.1038/srep05437

Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

Geraint Rogers, Justyna Kozlowska, Julie Keeble, K Metcalfe, M Fao, Scot Dowd, A. Mason, Michael McGuckin, Kenneth Bruce

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Abstract

Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

Original language	English
Article number	5437
Journal	Scientific Reports
Volume	4
Issue number	Art. No.: 5437
DOIs	https://doi.org/10.1038/srep05437
Publication status	Published - 25 Jun 2014

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abstract = "Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.",

author = "Geraint Rogers and Justyna Kozlowska and Julie Keeble and K Metcalfe and M Fao and Scot Dowd and A. Mason and Michael McGuckin and Kenneth Bruce",

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AU - Kozlowska, Justyna

AU - Keeble, Julie

AU - Metcalfe, K

AU - Fao, M

AU - Dowd, Scot

AU - Mason, A.

AU - McGuckin, Michael

AU - Bruce, Kenneth

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N2 - Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

AB - Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

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Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

Abstract

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