Functional Effects of Autoantibodies

Sally A. Waterman, Michael W. Jackson, Tom P. Gordon

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    5 Citations (Scopus)

    Abstract

    The functional autoantibodies have provided new insights into potential pathophysiologic mechanisms in numerous autoimmune diseases. Early detection of these autoantibodies and their removal by immunotherapy offers an additional approach to treatment that may halt disease progression and prevent the chronic irreversible changes that are typical of autoimmune disease. There is likely to be a large family of functional autoantibodies. The earliest functional autoantibodies detected in the neurologic diseases myasthenia gravis, Lambert-Eaton myasthenic syndrome (LEMS), and neuromyotonia, have their parallel in naturally occurring genetic disorders affecting the skeletal muscle nicotinic receptor, P/Q-type voltage-gated calcium channels (VGCCs), and voltage-gated potassium channels (VGKCs). It seems more than reasonable to assume that autoimmune equivalents can also be detected for diseases affecting other ion channels or receptors. It is noted that a better understanding of these autoantibodies is likely to enhance greatly our ability to diagnose, monitor, and treat the associated autoimmune diseases.

    Original languageEnglish
    Title of host publicationThe Autoimmune Diseases
    PublisherElsevier Inc.
    Chapter17
    Pages217-236
    Number of pages20
    Edition4
    ISBN (Print)9780125959612
    DOIs
    Publication statusPublished - 2006

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