Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery

Sandy Budi Hartono, Nghia Truong Phuoc, Meihua Yu, Zhongfan Jia, Michael J. Monteiro, Shizhang Qiao, Chengzhong Yu

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Novel mesoporous silica nanoparticles (LPMSNs) functionalised with degradable poly(2-dimethylaminoethyl acrylate) (PDMAEA) have been developed (PDMAEA-LPMSNs) as nano-carriers for gene delivery. The unique design of PDMAEA-LPMSNs has endowed this system with multiple functions derived from both the organic and inorganic moieties. The cationic polymer unit binds to genetic molecules and undergoes a self-catalyzed hydrolysis in water to form a non-toxic anionic polymer poly(acrylic acid), allowing controlled release of siRNA in the cells. The nanopores of the LPMSNs provide a reservoir for storage and release of chloroquine to facilitate endosomal escape. The PDMAEA-LPMSN composites were characterized by elemental analysis (EA), X-ray photoelectron spectroscopy (XPS), solid-state 13C magic-angle spinning nuclear magnetic resonance (MAS-NMR), thermogravimetric analysis (TGA), and nitrogen sorption techniques. Their siRNA delivery performance was tested in a KHOS cell line, showing promising potential for co-delivery of genes and drugs.

Original languageEnglish
Pages (from-to)718-726
Number of pages9
JournalJOURNAL OF MATERIALS CHEMISTRY B
Volume2
Issue number6
DOIs
Publication statusE-pub ahead of print - 12 Nov 2013
Externally publishedYes

Keywords

  • pore
  • mesoporous silica
  • nanoparticles
  • controlled release
  • co-delivery
  • functionalized

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