TY - JOUR
T1 - Functions of p38 MAP Kinases in the Central Nervous System
AU - Asih, Prita
AU - Prikas, Emmanuel
AU - Stefanoska, Kristie
AU - Tan, Amanda R.P.
AU - Ahel, Holly I.
AU - Ittner, Arne
PY - 2020/9/8
Y1 - 2020/9/8
N2 - Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a multitude of mammalian cell types. This review covers recent advances on specific functions of p38 MAP kinases in cells of the central nervous system. Unique and specific functions of the four mammalian p38 kinases are found in all major cell types in the brain. Mechanisms of p38 activation and downstream phosphorylation substrates in these different contexts are outlined and how they contribute to functions of p38 in physiological and under disease conditions. Results in different model organisms demonstrated that p38 kinases are involved in cognitive functions, including functions related to anxiety, addiction behavior, neurotoxicity, neurodegeneration, and decision making. Finally, the role of p38 kinases in psychiatric and neurological conditions and the current progress on therapeutic inhibitors targeting p38 kinases are covered and implicate p38 kinases in a multitude of CNS-related physiological and disease states.
AB - Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a multitude of mammalian cell types. This review covers recent advances on specific functions of p38 MAP kinases in cells of the central nervous system. Unique and specific functions of the four mammalian p38 kinases are found in all major cell types in the brain. Mechanisms of p38 activation and downstream phosphorylation substrates in these different contexts are outlined and how they contribute to functions of p38 in physiological and under disease conditions. Results in different model organisms demonstrated that p38 kinases are involved in cognitive functions, including functions related to anxiety, addiction behavior, neurotoxicity, neurodegeneration, and decision making. Finally, the role of p38 kinases in psychiatric and neurological conditions and the current progress on therapeutic inhibitors targeting p38 kinases are covered and implicate p38 kinases in a multitude of CNS-related physiological and disease states.
KW - astrocyte
KW - central nervous system
KW - microglia
KW - mitogen activated protein (MAP) kinase p38
KW - neuron
KW - oligodendrocyte
KW - signal transduction
UR - http://www.scopus.com/inward/record.url?scp=85091478839&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1143978
UR - http://purl.org/au-research/grants/ARC/DP200102396
UR - http://purl.org/au-research/grants/NHMRC/1176628
U2 - 10.3389/fnmol.2020.570586
DO - 10.3389/fnmol.2020.570586
M3 - Review article
AN - SCOPUS:85091478839
SN - 1662-5099
VL - 13
SP - 570
EP - 586
JO - Frontiers in Molecular Neuroscience
JF - Frontiers in Molecular Neuroscience
ER -