GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters

Sunita A. Ramesh, Stephen Donald Tyerman, Bo Xu, Jayakumar Bose, Satwinder Kaur, Vanessa M. Conn, Patrícia Domingos, Sana Ullah, Stefanie Wege, Sergey Shabala, José A. Feijó, Peter R. Ryan, Matthew Gilliham

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Abstract

The non-protein amino acid, gamma-aminobutyric acid (GABA) rapidly accumulates in plant tissues in response to biotic and abiotic stress, and regulates plant growth. Until now it was not known whether GABA exerts its effects in plants through the regulation of carbon metabolism or via an unidentified signalling pathway. Here, we demonstrate that anion flux through plant aluminium-activated malate transporter (ALMT) proteins is activated by anions and negatively regulated by GABA. Site-directed mutagenesis of selected amino acids within ALMT proteins abolishes GABA efficacy but does not alter other transport properties. GABA modulation of ALMT activity results in altered root growth and altered root tolerance to alkaline pH, acid pH and aluminium ions. We propose that GABA exerts its multiple physiological effects in plants via ALMT, including the regulation of pollen tube and root growth, and that GABA can finally be considered a legitimate signalling molecule in both the plant and animal kingdoms.

Original languageEnglish
Article number7879
Pages (from-to)1-10
Number of pages10
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 29 Jul 2015
Externally publishedYes

Bibliographical note

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Keywords

  • gamma-aminobutyric acid (GABA)
  • plant growth

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    Ramesh, S. A., Tyerman, S. D., Xu, B., Bose, J., Kaur, S., Conn, V. M., Domingos, P., Ullah, S., Wege, S., Shabala, S., Feijó, J. A., Ryan, P. R., & Gilliham, M. (2015). GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters. Nature Communications, 6, 1-10. [7879]. https://doi.org/10.1038/ncomms8879