Galanin was isolated in 1983 from porcine intestine by Tatemoto et al. using a chemical method designed for the detection of C-terminalamidated peptides. The isolated peptide was named galanin because of its N-terminal glycine and C-terminal alanine residue. Following this, galanin was isolated from other species, including humans. It is a neuropeptide that does not belong to any other family of neuropeptides. Galanin is involved in the regulation of a multitude of physiological conditions, ranging from central nervous system functions like cognition and memory, sensation of pain, feeding behaviour, and sexual behavior to endocrine functions such as influencing the release of insulin, acetylcholine, norepinephrine, glutamate, dopamine, growth hormone and prolactin, and finally also acting on gastrointestinal motility and secretion.
|Number of pages||12|
|Specialist publication||Pancreapedia: The Exocrine Pancreas Knowledge Base|
|Publisher||Michigan Publishing, University of Michigan Library|
|Publication status||Published - 27 Jun 2015|
- Porcine intestine
- amidated peptides
- 29 amino acid