Galanin-containing fibers innervate substance P-containing neurons in the pedunculopontine tegmental nucleus in humans

W. P. Gai, P. C. Blumbergs, L. B. Geffen, W. W. Blessing

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Galanin is a putative peptide transmitter distributed widely in the central nervous system. Galanin shows potent inhibitory effects on neuronal activity and learning behaviors induced or mediated by acetylcholine. Here, we demonstrate that in humans there are abundant galanin-containing fibers in the pedunculopontine tegmental nucleus, the lateral dorsal tegmental nucleus and the oral pontine reticular nucleus. These neurons contain both acetylcholine and substance P (SP). Using a double-immunostaining method, we show that galanin-containing terminals form pericellular baskets around many SP-positive neurons in these nuclei. Our results suggest galanin may influence brain functions via inputs to the ascending mesopontine acetylcholine-containing nuclei.

    Original languageEnglish
    Pages (from-to)135-141
    Number of pages7
    JournalBrain Research
    Volume618
    Issue number1
    DOIs
    Publication statusPublished - 30 Jul 1993

    Keywords

    • Ascending reticular cholinergic system
    • Galanin
    • Human brainstem
    • Pedunculopontine tegmental nucleus
    • Substance P

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