Gastric inlet patches: Symptomatic or silent?

Charles Cock, Zaki Hamarneh

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Purpose of reviewThe purpose of this review is to assess recent literature on the clinical relevance of the gastric inlet patch with particular focus on endoscopic diagnosis and treatment, the relationship of the inlet patch to laryngopharyngeal reflux disease and the association of proximal esophageal adenocarcinoma with inlet patch.Recent findingsRecent studies suggest endoscopic diagnosis of inlet patch increases with endoscopist awareness (up to 10-fold) and when using enhanced imaging techniques such as narrow band imaging (up to three-fold). The literature remains mixed on the association of inlet patch with laryngopharyngeal symptoms or globus sensation. Studies of endoscopic ablation, using argon plasma coagulation or radiofrequency ablation have shown improved laryngopharyngeal reflux symptom scores posttreatment. Proximal esophageal adenocarcinomas are rare but often associated with inlet patch when they occur. Case studies have described endoscopic resection of malignant lesions related to inlet patch, using endoscopic mucosal resection or submucosal dissection.SummaryProspective, multicenter studies of symptom association with inlet patch using validated symptom questionnaires and blinded sham-controlled treatments are needed to further clarify the role of such treatments, which to date are limited to a small numbers of centers with a special interest.

Original languageEnglish
Pages (from-to)453-462
Number of pages10
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number6
Publication statusPublished - 1 Dec 2019


  • cervical inlet patch
  • gastric inlet patch
  • heterotopic gastric mucosa
  • inlet patch
  • laryngopharyngeal reflux
  • proximal esophageal adenocarcinoma


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