Gastrointestinal and hepatotoxicity assessment of an anticancer extract from muricid molluscs

Chantel Westley, Kirsten Benkendorff, Cassandra McIver, Richard Le Leu, Catherine Abbott

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Marine molluscs from the family Muricidae are under development as a potential medicinal food for the prevention of colon cancer and treatment of gynaecological cancers. Here we report the outcome of the first in vivo toxicity assessment on an anticancer extract from a muricid mollusc containing brominated indole derivatives. Mice received the concentrated lipophilic extract by daily oral gavage over a two-week period. Mortality or clinical toxicity symptoms resulting from the extract were not detected during the trial, and there was no difference in the body weight of treated and control mice at the end of the trial. Histological analysis revealed some evidence for mild, idiosyncratic effects on the gastrointestinal tract and liver, including necrosis, fatty change, and inflammation in a small proportion (<40%) of mice. This is likely to result from first-pass hepatic metabolism of tyrindoxyl sulphate combined with second-pass metabolism of indoles. Overall however, oral administration of muricid extract containing brominated indoles does not result in severe clinical toxicity.

    Original languageEnglish
    Article number837370
    Pages (from-to)837370
    Number of pages12
    JournalEvidence-based Complementary and Alternative Medicine
    Volume2013
    DOIs
    Publication statusPublished - 2013

    Fingerprint Dive into the research topics of 'Gastrointestinal and hepatotoxicity assessment of an anticancer extract from muricid molluscs'. Together they form a unique fingerprint.

  • Cite this