Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders

L Wang, Michael Conlon, Claus Christophersen, Michael Sorich, Manya Angley

    Research output: Contribution to journalReview articlepeer-review

    47 Citations (Scopus)


    Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Many affected individuals also display symptoms of gastrointestinal (GI) disturbance, suggesting GI factors may play an important role in the pathogenesis of ASD and/or related complications. The current review will focus on evidence supporting a role for the GI microbiota and their fermentation products in the etiology and/or symptoms of ASD, and their potential use as biomarkers. GI-related biomarkers could potentially enable early identification of ASD at risk of GI disturbance, and thereby guide targeted interventions, potentially improving the health and quality of life of affected individuals.

    Original languageEnglish
    Pages (from-to)331-344
    Number of pages14
    JournalBiomarkers in Medicine
    Issue number3
    Publication statusPublished - Mar 2014


    • autism spectrum disorder
    • gastrointestinal
    • metabolite biomarkers
    • microbiota


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