Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination.

JO Miners, RA Robson, DJ Birkett

    Research output: Contribution to journalArticlepeer-review

    50 Citations (Scopus)

    Abstract

    The disposition of clofibric acid, a drug metabolised largely by glucuronidation, was studied in eight males, eight females and eight females receiving oral contraceptive steroids (OCS). Clofibric acid plasma clearance was not significantly different in males compared to the control female group but was 48% greater (P less than 0.01) in women receiving OCS compared to non‐pill using females. This difference was due to an alteration in clofibric acid metabolic clearance as there were no differences between the groups in clofibric acid free fraction. Along with previous data the results suggest that induction of drug glucuronidation by OCS may be of clinical importance, although any sex‐ related differences are unlikely to be of clinical significance. 1984 The British Pharmacological Society

    Original languageEnglish
    Pages (from-to)240-243
    Number of pages4
    JournalBritish Journal of Clinical Pharmacology
    Volume18
    Issue number2
    DOIs
    Publication statusPublished - Aug 1984

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