TY - JOUR
T1 - Generating and measuring photochemical changes inside the brain using optical fibers
T2 - exploring stroke
AU - Tsiminis, Georgios
AU - Klaric, Thomas
AU - Schartner, Erik
AU - Warren-Smith, Stephen
AU - Lewis, Martin
AU - Koblar, S
AU - Monro, Tanya
PY - 2014/11/1
Y1 - 2014/11/1
N2 - We report here on the development of a method for inducing a stroke in a specific location within a mouse brain through the use of an optical fiber. By capturing the emitted fluorescence signal generated using the same fiber it is possible to monitor photochemical changes within the brain in real-time, and directly measure the concentration of the strokeinducing dye, Rose Bengal, at the infarct site. This technique reduces the requirement for post-operative histology to determine if a stroke has successfully been induced within the animal, and therefore opens up the opportunity to explore the recovery of the brain after the stroke event.
AB - We report here on the development of a method for inducing a stroke in a specific location within a mouse brain through the use of an optical fiber. By capturing the emitted fluorescence signal generated using the same fiber it is possible to monitor photochemical changes within the brain in real-time, and directly measure the concentration of the strokeinducing dye, Rose Bengal, at the infarct site. This technique reduces the requirement for post-operative histology to determine if a stroke has successfully been induced within the animal, and therefore opens up the opportunity to explore the recovery of the brain after the stroke event.
UR - http://www.scopus.com/inward/record.url?scp=84942368769&partnerID=8YFLogxK
U2 - 10.1364/BOE.5.003975
DO - 10.1364/BOE.5.003975
M3 - Article
SN - 2156-7085
VL - 5
SP - 3975
EP - 3980
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 11
ER -