Generating and measuring photochemical changes inside the brain using optical fibers: exploring stroke

Georgios Tsiminis, Thomas Klaric, Erik Schartner, Stephen Warren-Smith, Martin Lewis, S Koblar, Tanya Monro

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    We report here on the development of a method for inducing a stroke in a specific location within a mouse brain through the use of an optical fiber. By capturing the emitted fluorescence signal generated using the same fiber it is possible to monitor photochemical changes within the brain in real-time, and directly measure the concentration of the strokeinducing dye, Rose Bengal, at the infarct site. This technique reduces the requirement for post-operative histology to determine if a stroke has successfully been induced within the animal, and therefore opens up the opportunity to explore the recovery of the brain after the stroke event.

    Original languageEnglish
    Pages (from-to)3975-3980
    Number of pages6
    JournalBiomedical Optics Express
    Volume5
    Issue number11
    DOIs
    Publication statusPublished - 2014

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