Generating and measuring photochemical changes inside the brain using optical fibers: exploring stroke

Georgios Tsiminis, Thomas Klaric, Erik Schartner, Stephen Warren-Smith, Martin Lewis, S Koblar, Tanya Monro

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

We report here on the development of a method for inducing a stroke in a specific location within a mouse brain through the use of an optical fiber. By capturing the emitted fluorescence signal generated using the same fiber it is possible to monitor photochemical changes within the brain in real-time, and directly measure the concentration of the strokeinducing dye, Rose Bengal, at the infarct site. This technique reduces the requirement for post-operative histology to determine if a stroke has successfully been induced within the animal, and therefore opens up the opportunity to explore the recovery of the brain after the stroke event.

Original languageEnglish
Pages (from-to)3975-3980
Number of pages6
JournalBiomedical Optics Express
Volume5
Issue number11
DOIs
Publication statusPublished - 1 Nov 2014
Externally publishedYes

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