Genome-wide association studies in the hunt for genes causing primary open-angle glaucoma: a review

Kathryn Burdon

    Research output: Contribution to journalReview articlepeer-review

    18 Citations (Scopus)

    Abstract

    Genome-wide association studies are a powerful tool for the identification of genetic risk factors for complex disease. This methodology has been successfully applied to primary open-angle glaucoma through the analysis of primary open-angle glaucoma (POAG) as well as specific subgroups of patients including those with normal tension glaucoma and advanced glaucoma. In addition, the analysis of quantitative traits important in POAG, including optic disc area and vertical cup-to-disc ratio has also identified genes important in POAG development. This review explores findings of genome-wide association studies for POAG and related traits.

    Original languageEnglish
    Pages (from-to)358-363
    Number of pages6
    JournalClinical and Experimental Ophthalmology
    Volume40
    Issue number4
    DOIs
    Publication statusPublished - May 2012

    Keywords

    • Endophenotype
    • Genetics
    • Primary open-angle glaucoma
    • Quantitative trait loci

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