Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

Chiea Khor; Tan Do; Hongyan Jia; Masakazu Nakano; Ronnie George; Khalid Abu-Amero; Roopam Duvesh; Li Chen; Zheng Li; Monisha Nongpiur; Shamira Perera; Chunyan Qiao; Hon-Tym Wong; Hiroshi Sakai; Monica de Melo; Mei Lee; Anita Chan; Azhany Yakub; Thi Dao; Yoko Ikeda; Rodolfo Perez-Grossmann; Tomasz Zarnowski; Alex Day; Jost Jonas; Pancy Tam; Tuan Tran; Humaira Ayub; Farah Akhtar; Shazia Michael; Paul Chew; Leyla Aljasim; Tanuj Dada; Tam Luu; Mona Awadalla; Naris Kitnarong; Boonsong Wanichwecharungruang; Yee Yee Aung; Jelinar Mohamed-Noor; Saravanan Vijayan; Sarangapani Sripriya; Rahat Husain; Aliza Jap; Baskaran Mani; David Goh; Daniel Su; Huaizhou Wang; Vernon Yong; Leonard Yip; Tuyet Trinh; Manchima Makornwattana; Thanh Nguyen; Edgar Leuenberger; Ki-Ho Park; Widya Wiyogo; Rajesh Kumar; Celso Tello; Yasuo Kurimoto; Suman Thapa; Kessara Pathanapitoon; John Salmon; Yong Ho Sohn; Antonio Fea; Ozaki Mineo; Jimmy Lai; Visanee Tantisevi; Chaw Chaw Khaing; Takanori Mizoguchi; Satoko Nakano; Chan-Yun Kim; Guangxian Tang; Sujie Fan; Renyi Wu; Hailin Meng; Thi Nguyen; Tien Tran; Morio Ueno; Jose Martinez; Norlina Ramli; Yin Aung; Rigo Reyes; Stephen Vernon; Seng Fang; Zhicheng Xie; Xiao Chen; Kar-Seng Sim; Tina Wong; Desmond Quek; Rangaraj Venkatesh; Srinivasan Kavitha; Subbaiah Krishnadas; Nagaswamy Soumittra; Balekudaru Shantha; Boon-Ang Lim; Jeanne Ogle; Jose de Vasconcellos; Vital Costa; Ricardo Abe; Bruno de Souza; Chelvin Sng; Maria Aquino; Ewa Kosior-Jarecka; Guillermo Fong; Vania Tamanaja; Ricardo Fujita; Yuzhen Jiang; Naushin Waseem; Sancy Low; Huan Pham; Sami Al Shahwan; E Craven; Muhammad Khan; Rrima Dada; Kuldeep Mohanty; Muneeb Faiq; Alex Hewitt; Kathryn Burdon; Eng Gan; Anuwat Prutthipongsit; Thipnapa Patthanathamrongkasem; Mary Ann Catacutan; Irene Felarca; Chona Liao; Emma Rusmayani; Vira Istiantoro; Giulia Consolandi; Giulia Pignata; Carlo Lavia; Prin Rojanapongpun; Lerprat Mangkornkanokpong; Sunee Chansangpetch; Jonathon Chan; Bonnie Choy; Jennifer Shum; Hlaing Than; Khin Oo; Aye Han; Victor Yong; Xiao Ng; Shuang Goh; Yaan Chong; Martin Hibberd; Mark Seielstad; Eileen Png; Sarah Dunstan; Nguyen van Vinh Chau; Jin-Xin Bei; Yi-Xin Zeng; Abhilasha Karkey; Buddha Basnyat; Francesca Pasutto; Daniela Paoli; Paolo Frezzotti; Jie Wang; Paul Mitchell; John Fingert; R Allingham; Michael Hauser; Soon Lim; Soo Chew; Richard Ebstein; Anavaj Sakuntabhai; Kyu Park; Jeeyun Ahn; Greet Boland; Harm Snippe; Richard Stead; Raquel Quino; Su Zaw; Urszula Lukasik; Rohit Shetty; Mimiwati Zahari; Hyoung Bae; Nay Lin Oo; Toshiaki Kubota; Anita Manassakorn; Wing Ho; Laura Dallorto; Young Hwang; Christine Kiire; Masako Kuroda; Zeiras Djamal; Jovell Peregrino; Arkasubhra Ghosh; Jin Jeoung; Tung Hoang; Nuttamon Srisamran; Thayanithi Sandragasu; Saw Set; Vi Doan; Shomi Bhattacharya; Ching-Lin Ho; Donald Tan; Ramanjit Sihota; Seng-Chee Loon; Kazuhiko Mori; Shigeru Kinoshita; Anneke den Hollander; Raheel Qamar; Ya Xing Wang; Yik Y Teo; E-Shyong Tai; Curt Hartleben-Matkin; David Lozano-Giral; Seang Mei Saw; Ching Yu Cheng; Juan Zenteno; Chi Pui Pang; Huong Bui; Owen Hee; Jamie Craig; Deepak Edward; Michiko Yonahara; Jamil Neto; Maria Guevara-Fujita; Liang Xu; Robert Ritch; Liza-Sharmini Tajudin; Tien Wong; Saleh Al-Obeidan; Do Hon; Periasamy Sundaresan; Clement Tham; Paul Foster; Lingam Vijaya; Kei Tashiro; Eranga Vithana; Ningli Wang; Tin Aung

doi:10.1038/ng.3540

Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

Chiea Khor, Tan Do, Hongyan Jia, Masakazu Nakano, Ronnie George, Khalid Abu-Amero, Roopam Duvesh, Li Chen, Zheng Li, Monisha Nongpiur, Shamira Perera, Chunyan Qiao, Hon-Tym Wong, Hiroshi Sakai, Monica de Melo, Mei Lee, Anita Chan, Azhany Yakub, Thi Dao, Yoko IkedaRodolfo Perez-Grossmann, Tomasz Zarnowski, Alex Day, Jost Jonas, Pancy Tam, Tuan Tran, Humaira Ayub, Farah Akhtar, Shazia Michael, Paul Chew, Leyla Aljasim, Tanuj Dada, Tam Luu, Mona Awadalla, Naris Kitnarong, Boonsong Wanichwecharungruang, Yee Yee Aung, Jelinar Mohamed-Noor, Saravanan Vijayan, Sarangapani Sripriya, Rahat Husain, Aliza Jap, Baskaran Mani, David Goh, Daniel Su, Huaizhou Wang, Vernon Yong, Leonard Yip, Tuyet Trinh, Manchima Makornwattana, Thanh Nguyen, Edgar Leuenberger, Ki-Ho Park, Widya Wiyogo, Rajesh Kumar, Celso Tello, Yasuo Kurimoto, Suman Thapa, Kessara Pathanapitoon, John Salmon, Yong Ho Sohn, Antonio Fea, Ozaki Mineo, Jimmy Lai, Visanee Tantisevi, Chaw Chaw Khaing, Takanori Mizoguchi, Satoko Nakano, Chan-Yun Kim, Guangxian Tang, Sujie Fan, Renyi Wu, Hailin Meng, Thi Nguyen, Tien Tran, Morio Ueno, Jose Martinez, Norlina Ramli, Yin Aung, Rigo Reyes, Stephen Vernon, Seng Fang, Zhicheng Xie, Xiao Chen, Kar-Seng Sim, Tina Wong, Desmond Quek, Rangaraj Venkatesh, Srinivasan Kavitha, Subbaiah Krishnadas, Nagaswamy Soumittra, Balekudaru Shantha, Boon-Ang Lim, Jeanne Ogle, Jose de Vasconcellos, Vital Costa, Ricardo Abe, Bruno de Souza, Chelvin Sng, Maria Aquino, Ewa Kosior-Jarecka, Guillermo Fong, Vania Tamanaja, Ricardo Fujita, Yuzhen Jiang, Naushin Waseem, Sancy Low, Huan Pham, Sami Al Shahwan, E Craven, Muhammad Khan, Rrima Dada, Kuldeep Mohanty, Muneeb Faiq, Alex Hewitt, Kathryn Burdon, Eng Gan, Anuwat Prutthipongsit, Thipnapa Patthanathamrongkasem, Mary Ann Catacutan, Irene Felarca, Chona Liao, Emma Rusmayani, Vira Istiantoro, Giulia Consolandi, Giulia Pignata, Carlo Lavia, Prin Rojanapongpun, Lerprat Mangkornkanokpong, Sunee Chansangpetch, Jonathon Chan, Bonnie Choy, Jennifer Shum, Hlaing Than, Khin Oo, Aye Han, Victor Yong, Xiao Ng, Shuang Goh, Yaan Chong, Martin Hibberd, Mark Seielstad, Eileen Png, Sarah Dunstan, Nguyen van Vinh Chau, Jin-Xin Bei, Yi-Xin Zeng, Abhilasha Karkey, Buddha Basnyat, Francesca Pasutto, Daniela Paoli, Paolo Frezzotti, Jie Wang, Paul Mitchell, John Fingert, R Allingham, Michael Hauser, Soon Lim, Soo Chew, Richard Ebstein, Anavaj Sakuntabhai, Kyu Park, Jeeyun Ahn, Greet Boland, Harm Snippe, Richard Stead, Raquel Quino, Su Zaw, Urszula Lukasik, Rohit Shetty, Mimiwati Zahari, Hyoung Bae, Nay Lin Oo, Toshiaki Kubota, Anita Manassakorn, Wing Ho, Laura Dallorto, Young Hwang, Christine Kiire, Masako Kuroda, Zeiras Djamal, Jovell Peregrino, Arkasubhra Ghosh, Jin Jeoung, Tung Hoang, Nuttamon Srisamran, Thayanithi Sandragasu, Saw Set, Vi Doan, Shomi Bhattacharya, Ching-Lin Ho, Donald Tan, Ramanjit Sihota, Seng-Chee Loon, Kazuhiko Mori, Shigeru Kinoshita, Anneke den Hollander, Raheel Qamar, Ya Xing Wang, Yik Y Teo, E-Shyong Tai, Curt Hartleben-Matkin, David Lozano-Giral, Seang Mei Saw, Ching Yu Cheng, Juan Zenteno, Chi Pui Pang, Huong Bui, Owen Hee, Jamie Craig, Deepak Edward, Michiko Yonahara, Jamil Neto, Maria Guevara-Fujita, Liang Xu, Robert Ritch, Liza-Sharmini Tajudin, Tien Wong, Saleh Al-Obeidan, Do Hon, Periasamy Sundaresan, Clement Tham, Paul Foster, Lingam Vijaya, Kei Tashiro, Eranga Vithana, Ningli Wang, Tin Aung

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10 -5), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10 -6), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10 -4), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10 -1), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10 -2). We also confirmed significant association at three previously described loci (P < 5 × 10 â'8 for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.

Original language	English
Pages (from-to)	556-562
Number of pages	7
Journal	Nature Genetics
Volume	48
Issue number	5
DOIs	https://doi.org/10.1038/ng.3540
Publication status	Published - 4 Apr 2016

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10.1038/ng.3540Licence: In Copyright

Cite this

Khor, C., Do, T., Jia, H., Nakano, M., George, R., Abu-Amero, K., Duvesh, R., Chen, L., Li, Z., Nongpiur, M., Perera, S., Qiao, C., Wong, H-T., Sakai, H., de Melo, M., Lee, M., Chan, A., Yakub, A., Dao, T., ... Aung, T. (2016). Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nature Genetics, 48(5), 556-562. https://doi.org/10.1038/ng.3540

@article{0a5239a295ad4c55bbb76d77868d341d,

title = "Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma",

abstract = "Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10 -5), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10 -6), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10 -4), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10 -1), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10 -2). We also confirmed significant association at three previously described loci (P < 5 × 10 {\^a}'8 for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.",

author = "Chiea Khor and Tan Do and Hongyan Jia and Masakazu Nakano and Ronnie George and Khalid Abu-Amero and Roopam Duvesh and Li Chen and Zheng Li and Monisha Nongpiur and Shamira Perera and Chunyan Qiao and Hon-Tym Wong and Hiroshi Sakai and {de Melo}, Monica and Mei Lee and Anita Chan and Azhany Yakub and Thi Dao and Yoko Ikeda and Rodolfo Perez-Grossmann and Tomasz Zarnowski and Alex Day and Jost Jonas and Pancy Tam and Tuan Tran and Humaira Ayub and Farah Akhtar and Shazia Michael and Paul Chew and Leyla Aljasim and Tanuj Dada and Tam Luu and Mona Awadalla and Naris Kitnarong and Boonsong Wanichwecharungruang and Aung, {Yee Yee} and Jelinar Mohamed-Noor and Saravanan Vijayan and Sarangapani Sripriya and Rahat Husain and Aliza Jap and Baskaran Mani and David Goh and Daniel Su and Huaizhou Wang and Vernon Yong and Leonard Yip and Tuyet Trinh and Manchima Makornwattana and Thanh Nguyen and Edgar Leuenberger and Ki-Ho Park and Widya Wiyogo and Rajesh Kumar and Celso Tello and Yasuo Kurimoto and Suman Thapa and Kessara Pathanapitoon and John Salmon and Sohn, {Yong Ho} and Antonio Fea and Ozaki Mineo and Jimmy Lai and Visanee Tantisevi and Khaing, {Chaw Chaw} and Takanori Mizoguchi and Satoko Nakano and Chan-Yun Kim and Guangxian Tang and Sujie Fan and Renyi Wu and Hailin Meng and Thi Nguyen and Tien Tran and Morio Ueno and Jose Martinez and Norlina Ramli and Yin Aung and Rigo Reyes and Stephen Vernon and Seng Fang and Zhicheng Xie and Xiao Chen and Kar-Seng Sim and Tina Wong and Desmond Quek and Rangaraj Venkatesh and Srinivasan Kavitha and Subbaiah Krishnadas and Nagaswamy Soumittra and Balekudaru Shantha and Boon-Ang Lim and Jeanne Ogle and {de Vasconcellos}, Jose and Vital Costa and Ricardo Abe and {de Souza}, Bruno and Chelvin Sng and Maria Aquino and Ewa Kosior-Jarecka and Guillermo Fong and Vania Tamanaja and Ricardo Fujita and Yuzhen Jiang and Naushin Waseem and Sancy Low and Huan Pham and {Al Shahwan}, Sami and E Craven and Muhammad Khan and Rrima Dada and Kuldeep Mohanty and Muneeb Faiq and Alex Hewitt and Kathryn Burdon and Eng Gan and Anuwat Prutthipongsit and Thipnapa Patthanathamrongkasem and Catacutan, {Mary Ann} and Irene Felarca and Chona Liao and Emma Rusmayani and Vira Istiantoro and Giulia Consolandi and Giulia Pignata and Carlo Lavia and Prin Rojanapongpun and Lerprat Mangkornkanokpong and Sunee Chansangpetch and Jonathon Chan and Bonnie Choy and Jennifer Shum and Hlaing Than and Khin Oo and Aye Han and Victor Yong and Xiao Ng and Shuang Goh and Yaan Chong and Martin Hibberd and Mark Seielstad and Eileen Png and Sarah Dunstan and {van Vinh Chau}, Nguyen and Jin-Xin Bei and Yi-Xin Zeng and Abhilasha Karkey and Buddha Basnyat and Francesca Pasutto and Daniela Paoli and Paolo Frezzotti and Jie Wang and Paul Mitchell and John Fingert and R Allingham and Michael Hauser and Soon Lim and Soo Chew and Richard Ebstein and Anavaj Sakuntabhai and Kyu Park and Jeeyun Ahn and Greet Boland and Harm Snippe and Richard Stead and Raquel Quino and Su Zaw and Urszula Lukasik and Rohit Shetty and Mimiwati Zahari and Hyoung Bae and Oo, {Nay Lin} and Toshiaki Kubota and Anita Manassakorn and Wing Ho and Laura Dallorto and Young Hwang and Christine Kiire and Masako Kuroda and Zeiras Djamal and Jovell Peregrino and Arkasubhra Ghosh and Jin Jeoung and Tung Hoang and Nuttamon Srisamran and Thayanithi Sandragasu and Saw Set and Vi Doan and Shomi Bhattacharya and Ching-Lin Ho and Donald Tan and Ramanjit Sihota and Seng-Chee Loon and Kazuhiko Mori and Shigeru Kinoshita and {den Hollander}, Anneke and Raheel Qamar and Wang, {Ya Xing} and Teo, {Yik Y} and E-Shyong Tai and Curt Hartleben-Matkin and David Lozano-Giral and Saw, {Seang Mei} and Cheng, {Ching Yu} and Juan Zenteno and Pang, {Chi Pui} and Huong Bui and Owen Hee and Jamie Craig and Deepak Edward and Michiko Yonahara and Jamil Neto and Maria Guevara-Fujita and Liang Xu and Robert Ritch and Liza-Sharmini Tajudin and Tien Wong and Saleh Al-Obeidan and Do Hon and Periasamy Sundaresan and Clement Tham and Paul Foster and Lingam Vijaya and Kei Tashiro and Eranga Vithana and Ningli Wang and Tin Aung",

year = "2016",

month = apr,

day = "4",

doi = "10.1038/ng.3540",

language = "English",

volume = "48",

pages = "556--562",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "5",

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Khor, C, Do, T, Jia, H, Nakano, M, George, R, Abu-Amero, K, Duvesh, R, Chen, L, Li, Z, Nongpiur, M, Perera, S, Qiao, C, Wong, H-T, Sakai, H, de Melo, M, Lee, M, Chan, A, Yakub, A, Dao, T, Ikeda, Y, Perez-Grossmann, R, Zarnowski, T, Day, A, Jonas, J, Tam, P, Tran, T, Ayub, H, Akhtar, F, Michael, S, Chew, P, Aljasim, L, Dada, T, Luu, T, Awadalla, M, Kitnarong, N, Wanichwecharungruang, B, Aung, YY, Mohamed-Noor, J, Vijayan, S, Sripriya, S, Husain, R, Jap, A, Mani, B, Goh, D, Su, D, Wang, H, Yong, V, Yip, L, Trinh, T, Makornwattana, M, Nguyen, T, Leuenberger, E, Park, K-H, Wiyogo, W, Kumar, R, Tello, C, Kurimoto, Y, Thapa, S, Pathanapitoon, K, Salmon, J, Sohn, YH, Fea, A, Mineo, O, Lai, J, Tantisevi, V, Khaing, CC, Mizoguchi, T, Nakano, S, Kim, C-Y, Tang, G, Fan, S, Wu, R, Meng, H, Nguyen, T, Tran, T, Ueno, M, Martinez, J, Ramli, N, Aung, Y, Reyes, R, Vernon, S, Fang, S, Xie, Z, Chen, X, Sim, K-S, Wong, T, Quek, D, Venkatesh, R, Kavitha, S, Krishnadas, S, Soumittra, N, Shantha, B, Lim, B-A, Ogle, J, de Vasconcellos, J, Costa, V, Abe, R, de Souza, B, Sng, C, Aquino, M, Kosior-Jarecka, E, Fong, G, Tamanaja, V, Fujita, R, Jiang, Y, Waseem, N, Low, S, Pham, H, Al Shahwan, S, Craven, E, Khan, M, Dada, R, Mohanty, K, Faiq, M, Hewitt, A, Burdon, K, Gan, E, Prutthipongsit, A, Patthanathamrongkasem, T, Catacutan, MA, Felarca, I, Liao, C, Rusmayani, E, Istiantoro, V, Consolandi, G, Pignata, G, Lavia, C, Rojanapongpun, P, Mangkornkanokpong, L, Chansangpetch, S, Chan, J, Choy, B, Shum, J, Than, H, Oo, K, Han, A, Yong, V, Ng, X, Goh, S, Chong, Y, Hibberd, M, Seielstad, M, Png, E, Dunstan, S, van Vinh Chau, N, Bei, J-X, Zeng, Y-X, Karkey, A, Basnyat, B, Pasutto, F, Paoli, D, Frezzotti, P, Wang, J, Mitchell, P, Fingert, J, Allingham, R, Hauser, M, Lim, S, Chew, S, Ebstein, R, Sakuntabhai, A, Park, K, Ahn, J, Boland, G, Snippe, H, Stead, R, Quino, R, Zaw, S, Lukasik, U, Shetty, R, Zahari, M, Bae, H, Oo, NL, Kubota, T, Manassakorn, A, Ho, W, Dallorto, L, Hwang, Y, Kiire, C, Kuroda, M, Djamal, Z, Peregrino, J, Ghosh, A, Jeoung, J, Hoang, T, Srisamran, N, Sandragasu, T, Set, S, Doan, V, Bhattacharya, S, Ho, C-L, Tan, D, Sihota, R, Loon, S-C, Mori, K, Kinoshita, S, den Hollander, A, Qamar, R, Wang, YX, Teo, YY, Tai, E-S, Hartleben-Matkin, C, Lozano-Giral, D, Saw, SM, Cheng, CY, Zenteno, J, Pang, CP, Bui, H, Hee, O, Craig, J, Edward, D, Yonahara, M, Neto, J, Guevara-Fujita, M, Xu, L, Ritch, R, Tajudin, L-S, Wong, T, Al-Obeidan, S, Hon, D, Sundaresan, P, Tham, C, Foster, P, Vijaya, L, Tashiro, K, Vithana, E, Wang, N & Aung, T 2016, 'Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma', Nature Genetics, vol. 48, no. 5, pp. 556-562. https://doi.org/10.1038/ng.3540

TY - JOUR

T1 - Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

AU - Khor, Chiea

AU - Do, Tan

AU - Jia, Hongyan

AU - Nakano, Masakazu

AU - George, Ronnie

AU - Abu-Amero, Khalid

AU - Duvesh, Roopam

AU - Chen, Li

AU - Li, Zheng

AU - Nongpiur, Monisha

AU - Perera, Shamira

AU - Qiao, Chunyan

AU - Wong, Hon-Tym

AU - Sakai, Hiroshi

AU - de Melo, Monica

AU - Lee, Mei

AU - Chan, Anita

AU - Yakub, Azhany

AU - Dao, Thi

AU - Ikeda, Yoko

AU - Perez-Grossmann, Rodolfo

AU - Zarnowski, Tomasz

AU - Day, Alex

AU - Jonas, Jost

AU - Tam, Pancy

AU - Tran, Tuan

AU - Ayub, Humaira

AU - Akhtar, Farah

AU - Michael, Shazia

AU - Chew, Paul

AU - Aljasim, Leyla

AU - Dada, Tanuj

AU - Luu, Tam

AU - Awadalla, Mona

AU - Kitnarong, Naris

AU - Wanichwecharungruang, Boonsong

AU - Aung, Yee Yee

AU - Mohamed-Noor, Jelinar

AU - Vijayan, Saravanan

AU - Sripriya, Sarangapani

AU - Husain, Rahat

AU - Jap, Aliza

AU - Mani, Baskaran

AU - Goh, David

AU - Su, Daniel

AU - Wang, Huaizhou

AU - Yong, Vernon

AU - Yip, Leonard

AU - Trinh, Tuyet

AU - Makornwattana, Manchima

AU - Nguyen, Thanh

AU - Leuenberger, Edgar

AU - Park, Ki-Ho

AU - Wiyogo, Widya

AU - Kumar, Rajesh

AU - Tello, Celso

AU - Kurimoto, Yasuo

AU - Thapa, Suman

AU - Pathanapitoon, Kessara

AU - Salmon, John

AU - Sohn, Yong Ho

AU - Fea, Antonio

AU - Mineo, Ozaki

AU - Lai, Jimmy

AU - Tantisevi, Visanee

AU - Khaing, Chaw Chaw

AU - Mizoguchi, Takanori

AU - Nakano, Satoko

AU - Kim, Chan-Yun

AU - Tang, Guangxian

AU - Fan, Sujie

AU - Wu, Renyi

AU - Meng, Hailin

AU - Nguyen, Thi

AU - Tran, Tien

AU - Ueno, Morio

AU - Martinez, Jose

AU - Ramli, Norlina

AU - Aung, Yin

AU - Reyes, Rigo

AU - Vernon, Stephen

AU - Fang, Seng

AU - Xie, Zhicheng

AU - Chen, Xiao

AU - Sim, Kar-Seng

AU - Wong, Tina

AU - Quek, Desmond

AU - Venkatesh, Rangaraj

AU - Kavitha, Srinivasan

AU - Krishnadas, Subbaiah

AU - Soumittra, Nagaswamy

AU - Shantha, Balekudaru

AU - Lim, Boon-Ang

AU - Ogle, Jeanne

AU - de Vasconcellos, Jose

AU - Costa, Vital

AU - Abe, Ricardo

AU - de Souza, Bruno

AU - Sng, Chelvin

AU - Aquino, Maria

AU - Kosior-Jarecka, Ewa

AU - Fong, Guillermo

AU - Tamanaja, Vania

AU - Fujita, Ricardo

AU - Jiang, Yuzhen

AU - Waseem, Naushin

AU - Low, Sancy

AU - Pham, Huan

AU - Al Shahwan, Sami

AU - Craven, E

AU - Khan, Muhammad

AU - Dada, Rrima

AU - Mohanty, Kuldeep

AU - Faiq, Muneeb

AU - Hewitt, Alex

AU - Burdon, Kathryn

AU - Gan, Eng

AU - Prutthipongsit, Anuwat

AU - Patthanathamrongkasem, Thipnapa

AU - Catacutan, Mary Ann

AU - Felarca, Irene

AU - Liao, Chona

AU - Rusmayani, Emma

AU - Istiantoro, Vira

AU - Consolandi, Giulia

AU - Pignata, Giulia

AU - Lavia, Carlo

AU - Rojanapongpun, Prin

AU - Mangkornkanokpong, Lerprat

AU - Chansangpetch, Sunee

AU - Chan, Jonathon

AU - Choy, Bonnie

AU - Shum, Jennifer

AU - Than, Hlaing

AU - Oo, Khin

AU - Han, Aye

AU - Yong, Victor

AU - Ng, Xiao

AU - Goh, Shuang

AU - Chong, Yaan

AU - Hibberd, Martin

AU - Seielstad, Mark

AU - Png, Eileen

AU - Dunstan, Sarah

AU - van Vinh Chau, Nguyen

AU - Bei, Jin-Xin

AU - Zeng, Yi-Xin

AU - Karkey, Abhilasha

AU - Basnyat, Buddha

AU - Pasutto, Francesca

AU - Paoli, Daniela

AU - Frezzotti, Paolo

AU - Wang, Jie

AU - Mitchell, Paul

AU - Fingert, John

AU - Allingham, R

AU - Hauser, Michael

AU - Lim, Soon

AU - Chew, Soo

AU - Ebstein, Richard

AU - Sakuntabhai, Anavaj

AU - Park, Kyu

AU - Ahn, Jeeyun

AU - Boland, Greet

AU - Snippe, Harm

AU - Stead, Richard

AU - Quino, Raquel

AU - Zaw, Su

AU - Lukasik, Urszula

AU - Shetty, Rohit

AU - Zahari, Mimiwati

AU - Bae, Hyoung

AU - Oo, Nay Lin

AU - Kubota, Toshiaki

AU - Manassakorn, Anita

AU - Ho, Wing

AU - Dallorto, Laura

AU - Hwang, Young

AU - Kiire, Christine

AU - Kuroda, Masako

AU - Djamal, Zeiras

AU - Peregrino, Jovell

AU - Ghosh, Arkasubhra

AU - Jeoung, Jin

AU - Hoang, Tung

AU - Srisamran, Nuttamon

AU - Sandragasu, Thayanithi

AU - Set, Saw

AU - Doan, Vi

AU - Bhattacharya, Shomi

AU - Ho, Ching-Lin

AU - Tan, Donald

AU - Sihota, Ramanjit

AU - Loon, Seng-Chee

AU - Mori, Kazuhiko

AU - Kinoshita, Shigeru

AU - den Hollander, Anneke

AU - Qamar, Raheel

AU - Wang, Ya Xing

AU - Teo, Yik Y

AU - Tai, E-Shyong

AU - Hartleben-Matkin, Curt

AU - Lozano-Giral, David

AU - Saw, Seang Mei

AU - Cheng, Ching Yu

AU - Zenteno, Juan

AU - Pang, Chi Pui

AU - Bui, Huong

AU - Hee, Owen

AU - Craig, Jamie

AU - Edward, Deepak

AU - Yonahara, Michiko

AU - Neto, Jamil

AU - Guevara-Fujita, Maria

AU - Xu, Liang

AU - Ritch, Robert

AU - Tajudin, Liza-Sharmini

AU - Wong, Tien

AU - Al-Obeidan, Saleh

AU - Hon, Do

AU - Sundaresan, Periasamy

AU - Tham, Clement

AU - Foster, Paul

AU - Vijaya, Lingam

AU - Tashiro, Kei

AU - Vithana, Eranga

AU - Wang, Ningli

AU - Aung, Tin

PY - 2016/4/4

Y1 - 2016/4/4

N2 - Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10 -5), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10 -6), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10 -4), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10 -1), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10 -2). We also confirmed significant association at three previously described loci (P < 5 × 10 â'8 for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.

AB - Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10 -5), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10 -6), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10 -4), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10 -1), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10 -2). We also confirmed significant association at three previously described loci (P < 5 × 10 â'8 for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.

UR - http://www.scopus.com/inward/record.url?scp=84963502585&partnerID=8YFLogxK

U2 - 10.1038/ng.3540

DO - 10.1038/ng.3540

M3 - Article

SN - 1061-4036

VL - 48

SP - 556

EP - 562

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

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