@article{89fe24cd99d84387987507a229c1d79a,
title = "Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma",
abstract = "Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10-8 to P = 10-190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.",
author = "{Alcohol Genome-wide Association (AlcGen) Consortium} and {Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study} and {Genetic Investigation of Anthropometric Traits (GIANT) Consortium} and {Global Lipids Genetics Consortium} and {Genetics of Liver Disease (GOLD) Consortium} and {International Consortium for Blood Pressure (ICBP-GWAS)} and {Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC)} and Chambers, {J. C.} and W. Zhang and J. Sehmi and X. Li and Wass, {M. N.} and {Van der Harst}, P. and H. Holm and S. Sanna and M. Kavousi and Baumeister, {S. E.} and Coin, {L. J.} and G. Deng and C. Gieger and Heard-Costa, {N. L.} and Hottenga, {J. J.} and B. K{\"u}hnel and V. Kumar and V. Lagou and L. Liang and J. Luan and Vidal, {P. M.} and {Mateo Leach}, I. and O'reilly, {P. F.} and Peden, {J. F.} and N. Rahmioglu and P. Soininen and Speliotes, {E. K.} and X. Yuan and G. Thorleifsson and Alizadeh, {B. Z.} and Atwood, {L. D.} and Borecki, {I. B.} and Brown, {M. J.} and P. Charoen and F. Cucca and D. Das and {de Geus}, {E. J.} and Dixon, {A. L.} and A. D{\"o}ring and G. Ehret and Eyjolfsson, {G. I.} and M. Farrall and Forouhi, {N. G.} and N. Friedrich and W. Goessling and Gudbjartsson, {D. F.} and Harris, {T. B.} and Hartikainen, {A. L.} and S. Heath and Hirschfield, {G. M.} and A. Hofman and G. Homuth and E. Hypp{\"o}nen and Janssen, {H. L.} and T. Johnson and Kangas, {A. J.} and Kema, {I. P.} and K{\"u}hn, {J. P.} and S. Lai and M. Lathrop and Lerch, {M. M.} and Y. Li and Liang, {T. J.} and Lin, {J. P.} and Loos, {R. J.} and Martin, {N. G.} and Moffatt, {M. F.} and Montgomery, {G. W.} and Munroe, {P. B.} and K. Musunuru and Y. Nakamura and O'donnell, {C. J.} and I. Olafsson and Penninx, {B. W.} and A. Pouta and Prins, {B. P.} and I. Prokopenko and R. Puls and A. Ruokonen and Savolainen, {M. J.} and D. Schlessinger and Schouten, {J. N.} and U. Seedorf and S. Sen-Chowdhry and Siminovitch, {K. A.} and Smit, {J. H.} and Spector, {T. D.} and W. Tan and Teslovich, {T. M.} and T. Tukiainen and Uitterlinden, {A. G.} and {Van der Klauw}, {M. M.} and Vasan, {R. S.} and C. Wallace and H. Wallaschofski and Wichmann, {H. E.} and G. Willemsen and P. W{\"u}rtz and C. Xu and Yerges-Armstrong, {L. M.} and Abecasis, {G. R.} and Ahmadi, {K. R.} and Boomsma, {D. I.} and M. Caulfield and Cookson, {W. O.} and {van Duijn}, {C. M.} and P. Froguel and K. Matsuda and McCarthy, {M. I.} and C. Meisinger and V. Mooser and Pietil{\"a}inen, {K. H.} and G. Schumann and H. Snieder and Sternberg, {M. J.} and Stolk, {R. P.} and Thomas, {H. C.} and U. Thorsteinsdottir and M. Uda and G. Waeber and Wareham, {N. J.} and Waterworth, {D. M.} and H. Watkins and Whitfield, {J. B.} and Witteman, {J. C.} and Wolffenbuttel, {B. H.} and Fox, {C. S.} and M. Ala-Korpela and K. Stefansson and P. Vollenweider and H. V{\"o}lzke and Schadt, {E. E.} and J. Scott and J{\"a}rvelin, {M. R.} and P. Elliott and Kooner, {J. S.} and Voight, {B. F.} and Scott, {L. J.} and V. Steinthorsdottir and Morris, {A. P.} and C. Dina and Welch, {R. P.} and E. Zeggini and C. Huth and Aulchenko, {Y. S.} and McCulloch, {L. J.} and T. Ferreira and H. Grallert and N. Amin and G. Wu and Willer, {C. J.} and S. Raychaudhuri and McCarroll, {S. A.} and C. Langenberg and Hofmann, {O. M.} and J. Dupuis and L. Qi and Segr{\`e}, {A. V.} and {van Hoek}, M. and Bennett, {A. J.} and G. Crawford and Elliott, {K. S.} and A. Elliott and T. Green and Jackson, {A. U.} and Johnson, {Paul R.V.} and N. Klopp and A. Kong and M. Li and Robertson, {N. R.} and Sampson, {M. J.} and Hunter, {D. J.} and Morris, {A. P.} and Palmer, {C. D.} and M. Walker and Harry Campbell and Daly, {M. J.} and R. Sladek and Wilson, {J. G.} and Wood, {A. R.} and Park, {J. H.} and Smith, {A. V.} and C. Hayward and Jacobs, {K. B.} and Zhao, {J. H.} and C. Chen and Cooper, {M. N.} and Thompson, {J. R.} and White, {C. C.} and J. Liu and Parker, {A. N.} and Peters, {M. J.} and Beilby, {J. P.} and Palmer, {L. J.} and Arnold, {A. M.} and P. Hall and S. Schreiber and Wright, {A. F.} and Lee, {J. Y.} and Smith, {J. D.} and Rose, {L. M.} and R. Roberts and Pedersen, {N. L.} and Hall, {A. S.} and Chen, {Y. D.} and Wilson, {J. G.} and Reilly, {M. P.} and Palmer, {C. D.} and M. Garcia and Clark, {J. M.} and Mitchell, {B. D.} and Carr, {J. Jeffrey} and K. Rice and Johnson, {A. D.} and F. Zhang and M. Alexander and Y. Liu and Nguyen, {K. D.} and Palmer, {N. D.} and Chang, {Y. P.} and Connell, {J. M.} and R. Collins and Young, {J. H.} and Lee, {N. R.} and Chen, {M. H.} and M. Islam and A. Taylor and Sun, {Y. V.} and E. Vartiainen and Wang, {T. J.} and X. Wang and H. Zhu and Smith, {N. L.} and G. Hilton and McKenzie, {C. A.} and Kim, {H. L.} and Smith, {G. D.} and A. Wong and Cooper, {J. A.} and P. Sharma and Kumar, {M. J.} and Cooper, {R. S.} and A. Elliott and X. Han and Manning, {A. K.} and Sutapa Mukherjee and D. Pearson and D. Varma and Ward, {K. L.} and Williams, {G. H.}",
year = "2011",
month = nov,
day = "1",
doi = "10.1038/ng.970",
language = "English",
volume = "43",
pages = "1131--1140",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "11",
}