Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence

Stephan B. Dreyer, Rosie Upstill-Goddard, Assya Legrini, Andrew V. Biankin, Glasgow Precision Oncology Laboratory, Australian Pancreatic Genome Initiative, John Chen, Mark E. Brooke-Smith

Research output: Contribution to journalLetterpeer-review

8 Citations (Scopus)
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Abstract

Pancreatic cancer (PC) remains a highly lethal malignancy, and most patients with localized disease that undergo surgical resection still succumb to recurrent disease. Pattern of recurrence after pancreatectomy is heterogenous, with some studies illustrating that site of recurrence can be associated with prognosis. Another study suggested that tumors that develop local and distant recurrence can be regarded as a homogenous disease with similar outcomes. Here we investigate novel molecular determinants of recurrence pattern after pancreatectomy for PC.

Recurrence patterns were classified as liver, lung, local only, and other distant, whereas the no recurrence group was defined as those that did not develop any recurrence during the study period (minimum of 24 months of follow-up). Genomic, transcriptomic, immunohistochemical, and clinical data of primary resected tumor specimens from the Australian Pancreatic Cancer Genome Initiative (Australian contribution to the International Cancer Genome Consortium) PC cohort were used in the molecular analysis (n = 435). Full methods and description of cohort undergoing each analysis are available in the Supplementary Methods section.
Original languageEnglish
Pages (from-to)320-324.e4
Number of pages9
JournalGastroenterology
Volume162
Issue number1
Early online date14 Sep 2021
DOIs
Publication statusPublished - Jan 2022
Externally publishedYes

Keywords

  • Pancreatic cancer
  • Pancreatectomy
  • Recurrent disease
  • Genomic analysis
  • Molecular analysis

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