Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases

McKinzie K.A. Garrison; Yeongjun Jang; Taejeong Bae; Adriana Cherskov; Sarah B. Emery; Liana Fasching; Attila Jones; John B. Moldovan; Cindy Molitor; Sirisha Pochareddy; Mette A. Peters; Joo Heon Shin; Yifan Wang; Xiaoxu Yang; Schahram Akbarian; Andrew Chess; Fred H. Gage; Joseph G. Gleeson; Jeffrey M. Kidd; Michael McConnell; Ryan E. Mills; John V. Moran; Peter J. Park; Nenad Sestan; Alexander E. Urban; Flora M. Vaccarino; Christopher A. Walsh; Daniel R. Weinberger; Sarah J. Wheelan; Alexej Abyzov; BSMN Consortium; Jennifer Erwin

doi:10.1038/s41597-023-02645-7

Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases

McKinzie K.A. Garrison
, Yeongjun Jang
, Taejeong Bae
, Adriana Cherskov
, Sarah B. Emery
, Liana Fasching
, Attila Jones
, John B. Moldovan
, Cindy Molitor
, Sirisha Pochareddy
, Mette A. Peters
, Joo Heon Shin
, Yifan Wang
, Xiaoxu Yang
, Schahram Akbarian
, Andrew Chess
, Fred H. Gage
, Joseph G. Gleeson
, Jeffrey M. Kidd
, Michael McConnell

Ryan E. Mills, John V. Moran, Peter J. Park, Nenad Sestan, Alexander E. Urban, Flora M. Vaccarino, Christopher A. Walsh, Daniel R. Weinberger, Sarah J. Wheelan, Alexej Abyzov, BSMN Consortium, Jennifer Erwin

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

34 Downloads (Pure)

Abstract

Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in autism spectrum disorder, bipolar disorder, focal cortical dysplasia, schizophrenia, and Tourette syndrome, a multi-institutional consortium called the Brain Somatic Mosaicism Network (BSMN) was formed through the National Institute of Mental Health (NIMH). In addition to genomic data of affected and neurotypical brains, the BSMN also developed and validated a best practices somatic single nucleotide variant calling workflow through the analysis of reference brain tissue. These resources, which include >400 terabytes of data from 1087 subjects, are now available to the research community via the NIMH Data Archive (NDA) and are described here.

Original language	English
Article number	813
Number of pages	18
Journal	Scientific Data
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41597-023-02645-7
Publication status	Published - Dec 2023
Externally published	Yes

Keywords

Somatic mosaicism
Genomic sequencing
Genomic data
Neuropsychiatric disorders
Brain Somatic Mosaicism Network

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10.1038/s41597-023-02645-7Licence: CC BY

Published versionFinal published version, 2.02 MBLicence: CC BY

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Garrison, M. K. A., Jang, Y., Bae, T., Cherskov, A., Emery, S. B., Fasching, L., Jones, A., Moldovan, J. B., Molitor, C., Pochareddy, S., Peters, M. A., Shin, J. H., Wang, Y., Yang, X., Akbarian, S., Chess, A., Gage, F. H., Gleeson, J. G., Kidd, J. M., ... Erwin, J. (2023). Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases. Scientific Data, 10(1), Article 813. https://doi.org/10.1038/s41597-023-02645-7

@article{e7f71fe350db44c3afb9ebe7a4e38252,

title = "Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases",

abstract = "Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in autism spectrum disorder, bipolar disorder, focal cortical dysplasia, schizophrenia, and Tourette syndrome, a multi-institutional consortium called the Brain Somatic Mosaicism Network (BSMN) was formed through the National Institute of Mental Health (NIMH). In addition to genomic data of affected and neurotypical brains, the BSMN also developed and validated a best practices somatic single nucleotide variant calling workflow through the analysis of reference brain tissue. These resources, which include >400 terabytes of data from 1087 subjects, are now available to the research community via the NIMH Data Archive (NDA) and are described here.",

keywords = "Somatic mosaicism, Genomic sequencing, Genomic data, Neuropsychiatric disorders, Brain Somatic Mosaicism Network",

author = "Garrison, \{McKinzie K.A.\} and Yeongjun Jang and Taejeong Bae and Adriana Cherskov and Emery, \{Sarah B.\} and Liana Fasching and Attila Jones and Moldovan, \{John B.\} and Cindy Molitor and Sirisha Pochareddy and Peters, \{Mette A.\} and Shin, \{Joo Heon\} and Yifan Wang and Xiaoxu Yang and Schahram Akbarian and Andrew Chess and Gage, \{Fred H.\} and Gleeson, \{Joseph G.\} and Kidd, \{Jeffrey M.\} and Michael McConnell and Mills, \{Ryan E.\} and Moran, \{John V.\} and Park, \{Peter J.\} and Nenad Sestan and Urban, \{Alexander E.\} and Vaccarino, \{Flora M.\} and Walsh, \{Christopher A.\} and Weinberger, \{Daniel R.\} and Wheelan, \{Sarah J.\} and Alexej Abyzov and \{BSMN Consortium\} and Amero, \{Aitor Serres\} and Danny Antaki and Dan Averbuj and Laurel Ball and Sara Bizzotto and Craig Bohrson and Rebeca Borges-Monroy and Martin Breuss and Sean Cho and Chong Chu and Changuk Chung and Isidro Cortes-Ciriano and Michael Coulter and Kenneth Daily and Caroline Dias and Alissa D{\textquoteright}Gama and Yanmei Dou and Jennifer Erwin and Flasch, \{Diane A.\} and Frisbie, \{Trenton J.\} and Alon Galor and Javier Ganz and Doga Gulhan and Robert Hill and Huang, \{August Yue\} and Andrew Jaffe and Alexandre Jourdon and David Juan and Sattar Khoshkhoo and Sonia Kim and Kopera, \{Huira C.\} and Kwan, \{Kenneth Y.\} and Minseok Kwon and Ben Langmead and Lee, \{Eunjung Alice\} and Sara Linker and Irene Lobon and Lodato, \{Michael A.\} and Luquette, \{Lovelace J.\} and Gary Mathern and Tomas Marques-Bonet and Maury, \{Eduardo A.\} and Michael Miller and Moruno, \{Manuel Solis\} and Rujuta Narurkar and Apua Paquola and Reenal Pattni and Perez, \{Raquel Garcia\} and Inna Povolotskaya and Patrick Reed and Rachel Rodin and Chaggai Rosenbluh and Soraya Scuderi and Maxwell Sherman and Richard Straub and Eduardo Soriano and Chen Sun and Jeremy Thorpe and Vinay Viswanadham and Meiyan Wang and Xuefang Zhao and Bo Zhou and Weichen Zhou and Zinan Zhou and Xiaowei Zhu",

year = "2023",

month = dec,

doi = "10.1038/s41597-023-02645-7",

language = "English",

volume = "10",

journal = "Scientific Data",

issn = "2052-4463",

publisher = "medRxiv, Cold Spring Harbor Laboratory",

number = "1",

}

Garrison, MKA, Jang, Y, Bae, T, Cherskov, A, Emery, SB, Fasching, L, Jones, A, Moldovan, JB, Molitor, C, Pochareddy, S, Peters, MA, Shin, JH, Wang, Y, Yang, X, Akbarian, S, Chess, A, Gage, FH, Gleeson, JG, Kidd, JM, McConnell, M, Mills, RE, Moran, JV, Park, PJ, Sestan, N, Urban, AE, Vaccarino, FM, Walsh, CA, Weinberger, DR, Wheelan, SJ, Abyzov, A, BSMN Consortium & Erwin, J 2023, 'Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases', Scientific Data, vol. 10, no. 1, 813. https://doi.org/10.1038/s41597-023-02645-7

TY - JOUR

T1 - Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases

AU - Garrison, McKinzie K.A.

AU - Jang, Yeongjun

AU - Bae, Taejeong

AU - Cherskov, Adriana

AU - Emery, Sarah B.

AU - Fasching, Liana

AU - Jones, Attila

AU - Moldovan, John B.

AU - Molitor, Cindy

AU - Pochareddy, Sirisha

AU - Peters, Mette A.

AU - Shin, Joo Heon

AU - Wang, Yifan

AU - Yang, Xiaoxu

AU - Akbarian, Schahram

AU - Chess, Andrew

AU - Gage, Fred H.

AU - Gleeson, Joseph G.

AU - Kidd, Jeffrey M.

AU - McConnell, Michael

AU - Mills, Ryan E.

AU - Moran, John V.

AU - Park, Peter J.

AU - Sestan, Nenad

AU - Urban, Alexander E.

AU - Vaccarino, Flora M.

AU - Walsh, Christopher A.

AU - Weinberger, Daniel R.

AU - Wheelan, Sarah J.

AU - Abyzov, Alexej

AU - BSMN Consortium

AU - Amero, Aitor Serres

AU - Antaki, Danny

AU - Averbuj, Dan

AU - Ball, Laurel

AU - Bizzotto, Sara

AU - Bohrson, Craig

AU - Borges-Monroy, Rebeca

AU - Breuss, Martin

AU - Cho, Sean

AU - Chu, Chong

AU - Chung, Changuk

AU - Cortes-Ciriano, Isidro

AU - Coulter, Michael

AU - Daily, Kenneth

AU - Dias, Caroline

AU - D’Gama, Alissa

AU - Dou, Yanmei

AU - Erwin, Jennifer

AU - Flasch, Diane A.

AU - Frisbie, Trenton J.

AU - Galor, Alon

AU - Ganz, Javier

AU - Gulhan, Doga

AU - Hill, Robert

AU - Huang, August Yue

AU - Jaffe, Andrew

AU - Jourdon, Alexandre

AU - Juan, David

AU - Khoshkhoo, Sattar

AU - Kim, Sonia

AU - Kopera, Huira C.

AU - Kwan, Kenneth Y.

AU - Kwon, Minseok

AU - Langmead, Ben

AU - Lee, Eunjung Alice

AU - Linker, Sara

AU - Lobon, Irene

AU - Lodato, Michael A.

AU - Luquette, Lovelace J.

AU - Mathern, Gary

AU - Marques-Bonet, Tomas

AU - Maury, Eduardo A.

AU - Miller, Michael

AU - Moruno, Manuel Solis

AU - Narurkar, Rujuta

AU - Paquola, Apua

AU - Pattni, Reenal

AU - Perez, Raquel Garcia

AU - Povolotskaya, Inna

AU - Reed, Patrick

AU - Rodin, Rachel

AU - Rosenbluh, Chaggai

AU - Scuderi, Soraya

AU - Sherman, Maxwell

AU - Straub, Richard

AU - Soriano, Eduardo

AU - Sun, Chen

AU - Thorpe, Jeremy

AU - Viswanadham, Vinay

AU - Wang, Meiyan

AU - Zhao, Xuefang

AU - Zhou, Bo

AU - Zhou, Weichen

AU - Zhou, Zinan

AU - Zhu, Xiaowei

PY - 2023/12

Y1 - 2023/12

N2 - Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in autism spectrum disorder, bipolar disorder, focal cortical dysplasia, schizophrenia, and Tourette syndrome, a multi-institutional consortium called the Brain Somatic Mosaicism Network (BSMN) was formed through the National Institute of Mental Health (NIMH). In addition to genomic data of affected and neurotypical brains, the BSMN also developed and validated a best practices somatic single nucleotide variant calling workflow through the analysis of reference brain tissue. These resources, which include >400 terabytes of data from 1087 subjects, are now available to the research community via the NIMH Data Archive (NDA) and are described here.

AB - Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in autism spectrum disorder, bipolar disorder, focal cortical dysplasia, schizophrenia, and Tourette syndrome, a multi-institutional consortium called the Brain Somatic Mosaicism Network (BSMN) was formed through the National Institute of Mental Health (NIMH). In addition to genomic data of affected and neurotypical brains, the BSMN also developed and validated a best practices somatic single nucleotide variant calling workflow through the analysis of reference brain tissue. These resources, which include >400 terabytes of data from 1087 subjects, are now available to the research community via the NIMH Data Archive (NDA) and are described here.

KW - Somatic mosaicism

KW - Genomic sequencing

KW - Genomic data

KW - Neuropsychiatric disorders

KW - Brain Somatic Mosaicism Network

UR - https://www.scopus.com/pages/publications/85177445892

U2 - 10.1038/s41597-023-02645-7

DO - 10.1038/s41597-023-02645-7

M3 - Article

C2 - 37985666

AN - SCOPUS:85177445892

SN - 2052-4463

VL - 10

JO - Scientific Data

JF - Scientific Data

IS - 1

M1 - 813

ER -

Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases

Abstract

Keywords

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