Giant tortoise genomes provide insights into longevity and age-related disease

Víctor Quesada; Sandra Freitas-Rodríguez; Joshua Miller; José G. Pérez-Silva; Zi Feng Jiang; Washington Tapia; Olaya Santiago-Fernández; Diana Campos-Iglesias; Lukas F.K. Kuderna; Maud Quinzin; Miguel G. Álvarez; Dido Carrero; Luciano B. Beheregaray; James P. Gibbs; Ylenia Chiari; Scott Glaberman; Claudio Ciofi; Miguel Araujo-Voces; Pablo Mayoral; Javier R. Arango; Isaac Tamargo-Gómez; David Roiz-Valle; María Pascual-Torner; Benjamin R. Evans; Danielle L. Edwards; Ryan C. Garrick; Michael A. Russello; Nikos Poulakakis; Stephen J. Gaughran; Danny O. Rueda; Gabriel Bretones; Tomàs Marquès-Bonet; Kevin P. White; Adalgisa Caccone; Carlos López-Otín

doi:10.1038/s41559-018-0733-x

Giant tortoise genomes provide insights into longevity and age-related disease

Víctor Quesada
, Sandra Freitas-Rodríguez
, Joshua Miller
, José G. Pérez-Silva
, Zi Feng Jiang
, Washington Tapia
, Olaya Santiago-Fernández
, Diana Campos-Iglesias
, Lukas F.K. Kuderna
, Maud Quinzin
, Miguel G. Álvarez
, Dido Carrero
, Luciano B. Beheregaray
, James P. Gibbs
, Ylenia Chiari
, Scott Glaberman
, Claudio Ciofi
, Miguel Araujo-Voces
, Pablo Mayoral
, Javier R. Arango

Isaac Tamargo-Gómez, David Roiz-Valle, María Pascual-Torner, Benjamin R. Evans, Danielle L. Edwards, Ryan C. Garrick, Michael A. Russello, Nikos Poulakakis, Stephen J. Gaughran, Danny O. Rueda, Gabriel Bretones, Tomàs Marquès-Bonet, Kevin P. White, Adalgisa Caccone, Carlos López-Otín

College of Science and Engineering

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

148 Downloads (Pure)

Abstract

Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Here, we describe a global analysis of the genomes of Lonesome George—the iconic last member of Chelonoidis abingdonii—and the Aldabra giant tortoise (Aldabrachelys gigantea). Comparison of these genomes with those of related species, using both unsupervised and supervised analyses, led us to detect lineage-specific variants affecting DNA repair genes, inflammatory mediators and genes related to cancer development. Our study also hints at specific evolutionary strategies linked to increased lifespan, and expands our understanding of the genomic determinants of ageing. These new genome sequences also provide important resources to help the efforts for restoration of giant tortoise populations.

Original language	English
Pages (from-to)	87-95
Number of pages	9
Journal	Nature Ecology & Evolution
Volume	3
Issue number	1
Early online date	3 Dec 2018
DOIs	https://doi.org/10.1038/s41559-018-0733-x
Publication status	Published - Jan 2019

Bibliographical note

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s41559-018-0733-xLicence: CC BY

Published versionFinal published version, 1.87 MBLicence: CC BY

Cite this

Quesada, V., Freitas-Rodríguez, S., Miller, J., Pérez-Silva, J. G., Jiang, Z. F., Tapia, W., Santiago-Fernández, O., Campos-Iglesias, D., Kuderna, L. F. K., Quinzin, M., Álvarez, M. G., Carrero, D., Beheregaray, L. B., Gibbs, J. P., Chiari, Y., Glaberman, S., Ciofi, C., Araujo-Voces, M., Mayoral, P., ... López-Otín, C. (2019). Giant tortoise genomes provide insights into longevity and age-related disease. Nature Ecology & Evolution, 3(1), 87-95. https://doi.org/10.1038/s41559-018-0733-x

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title = "Giant tortoise genomes provide insights into longevity and age-related disease",

abstract = "Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Here, we describe a global analysis of the genomes of Lonesome George—the iconic last member of Chelonoidis abingdonii—and the Aldabra giant tortoise (Aldabrachelys gigantea). Comparison of these genomes with those of related species, using both unsupervised and supervised analyses, led us to detect lineage-specific variants affecting DNA repair genes, inflammatory mediators and genes related to cancer development. Our study also hints at specific evolutionary strategies linked to increased lifespan, and expands our understanding of the genomic determinants of ageing. These new genome sequences also provide important resources to help the efforts for restoration of giant tortoise populations.",

author = "V{\'i}ctor Quesada and Sandra Freitas-Rodr{\'i}guez and Joshua Miller and P{\'e}rez-Silva, \{Jos{\'e} G.\} and Jiang, \{Zi Feng\} and Washington Tapia and Olaya Santiago-Fern{\'a}ndez and Diana Campos-Iglesias and Kuderna, \{Lukas F.K.\} and Maud Quinzin and {\'A}lvarez, \{Miguel G.\} and Dido Carrero and Beheregaray, \{Luciano B.\} and Gibbs, \{James P.\} and Ylenia Chiari and Scott Glaberman and Claudio Ciofi and Miguel Araujo-Voces and Pablo Mayoral and Arango, \{Javier R.\} and Isaac Tamargo-G{\'o}mez and David Roiz-Valle and Mar{\'i}a Pascual-Torner and Evans, \{Benjamin R.\} and Edwards, \{Danielle L.\} and Garrick, \{Ryan C.\} and Russello, \{Michael A.\} and Nikos Poulakakis and Gaughran, \{Stephen J.\} and Rueda, \{Danny O.\} and Gabriel Bretones and Tom{\`a}s Marqu{\`e}s-Bonet and White, \{Kevin P.\} and Adalgisa Caccone and Carlos L{\'o}pez-Ot{\'i}n",

note = "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article{\textquoteright}s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article{\textquoteright}s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.",

year = "2019",

month = jan,

doi = "10.1038/s41559-018-0733-x",

language = "English",

volume = "3",

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journal = "Nature Ecology \& Evolution",

issn = "2397-334X",

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Quesada, V, Freitas-Rodríguez, S, Miller, J, Pérez-Silva, JG, Jiang, ZF, Tapia, W, Santiago-Fernández, O, Campos-Iglesias, D, Kuderna, LFK, Quinzin, M, Álvarez, MG, Carrero, D, Beheregaray, LB, Gibbs, JP, Chiari, Y, Glaberman, S, Ciofi, C, Araujo-Voces, M, Mayoral, P, Arango, JR, Tamargo-Gómez, I, Roiz-Valle, D, Pascual-Torner, M, Evans, BR, Edwards, DL, Garrick, RC, Russello, MA, Poulakakis, N, Gaughran, SJ, Rueda, DO, Bretones, G, Marquès-Bonet, T, White, KP, Caccone, A & López-Otín, C 2019, 'Giant tortoise genomes provide insights into longevity and age-related disease', Nature Ecology & Evolution, vol. 3, no. 1, pp. 87-95. https://doi.org/10.1038/s41559-018-0733-x

TY - JOUR

T1 - Giant tortoise genomes provide insights into longevity and age-related disease

AU - Quesada, Víctor

AU - Freitas-Rodríguez, Sandra

AU - Miller, Joshua

AU - Pérez-Silva, José G.

AU - Jiang, Zi Feng

AU - Tapia, Washington

AU - Santiago-Fernández, Olaya

AU - Campos-Iglesias, Diana

AU - Kuderna, Lukas F.K.

AU - Quinzin, Maud

AU - Álvarez, Miguel G.

AU - Carrero, Dido

AU - Beheregaray, Luciano B.

AU - Gibbs, James P.

AU - Chiari, Ylenia

AU - Glaberman, Scott

AU - Ciofi, Claudio

AU - Araujo-Voces, Miguel

AU - Mayoral, Pablo

AU - Arango, Javier R.

AU - Tamargo-Gómez, Isaac

AU - Roiz-Valle, David

AU - Pascual-Torner, María

AU - Evans, Benjamin R.

AU - Edwards, Danielle L.

AU - Garrick, Ryan C.

AU - Russello, Michael A.

AU - Poulakakis, Nikos

AU - Gaughran, Stephen J.

AU - Rueda, Danny O.

AU - Bretones, Gabriel

AU - Marquès-Bonet, Tomàs

AU - White, Kevin P.

AU - Caccone, Adalgisa

AU - López-Otín, Carlos

N1 - Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PY - 2019/1

Y1 - 2019/1

N2 - Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Here, we describe a global analysis of the genomes of Lonesome George—the iconic last member of Chelonoidis abingdonii—and the Aldabra giant tortoise (Aldabrachelys gigantea). Comparison of these genomes with those of related species, using both unsupervised and supervised analyses, led us to detect lineage-specific variants affecting DNA repair genes, inflammatory mediators and genes related to cancer development. Our study also hints at specific evolutionary strategies linked to increased lifespan, and expands our understanding of the genomic determinants of ageing. These new genome sequences also provide important resources to help the efforts for restoration of giant tortoise populations.

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Giant tortoise genomes provide insights into longevity and age-related disease

Abstract

Bibliographical note

UN SDGs

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