Global burden of peripheral artery disease and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

GBD 2019 Peripheral Artery Disease Collaborators; Seyed Afshin Shorofi

doi:10.1016/S2214-109X(23)00355-8

Global burden of peripheral artery disease and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

GBD 2019 Peripheral Artery Disease Collaborators, Seyed Afshin Shorofi

College of Nursing and Health Sciences

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

7 Downloads (Pure)

Abstract

Background: Peripheral artery disease is a growing public health problem. We aimed to estimate the global disease burden of peripheral artery disease, its risk factors, and temporospatial trends to inform policy and public measures.

Methods: Data on peripheral artery disease were modelled using the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 database. Prevalence, disability-adjusted life years (DALYs), and mortality estimates of peripheral artery disease were extracted from GBD 2019. Total DALYs and age-standardised DALY rate of peripheral artery disease attributed to modifiable risk factors were also assessed.

Findings: In 2019, the number of people aged 40 years and older with peripheral artery disease was 113 million (95% uncertainty interval [UI] 99·2–128·4), with a global prevalence of 1·52% (95% UI 1·33–1·72), of which 42·6% was in countries with low to middle Socio-demographic Index (SDI). The global prevalence of peripheral artery disease was higher in older people, (14·91% [12·41–17·87] in those aged 80–84 years), and was generally higher in females than in males. Globally, the total number of DALYs attributable to modifiable risk factors in 2019 accounted for 69·4% (64·2–74·3) of total peripheral artery disease DALYs. The prevalence of peripheral artery disease was highest in countries with high SDI and lowest in countries with low SDI, whereas DALY and mortality rates showed U-shaped curves, with the highest burden in the high and low SDI quintiles.

Interpretation: The total number of people with peripheral artery disease has increased globally from 1990 to 2019. Despite the lower prevalence of peripheral artery disease in males and low-income countries, these groups showed similar DALY rates to females and higher-income countries, highlighting disproportionate burden in these groups. Modifiable risk factors were responsible for around 70% of the global peripheral artery disease burden. Public measures could mitigate the burden of peripheral artery disease by modifying risk factors.

Funding: Bill & Melinda Gates Foundation.

Original language	English
Pages (from-to)	e1553-e1565
Number of pages	13
Journal	The Lancet Global Health
Volume	11
Issue number	10
Early online date	19 Sept 2023
DOIs	https://doi.org/10.1016/S2214-109X(23)00355-8
Publication status	Published - Oct 2023

Keywords

Global Burden of Disease
Peripheral arterial disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S2214-109X(23)00355-8Licence: CC BY

Final published versionFinal published version, 1.33 MBLicence: CC BY

Cite this

@article{10c6053a26df4bd88741ef5ffce741b9,

title = "Global burden of peripheral artery disease and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019",

abstract = "Background: Peripheral artery disease is a growing public health problem. We aimed to estimate the global disease burden of peripheral artery disease, its risk factors, and temporospatial trends to inform policy and public measures. Methods: Data on peripheral artery disease were modelled using the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 database. Prevalence, disability-adjusted life years (DALYs), and mortality estimates of peripheral artery disease were extracted from GBD 2019. Total DALYs and age-standardised DALY rate of peripheral artery disease attributed to modifiable risk factors were also assessed. Findings: In 2019, the number of people aged 40 years and older with peripheral artery disease was 113 million (95% uncertainty interval [UI] 99·2–128·4), with a global prevalence of 1·52% (95% UI 1·33–1·72), of which 42·6% was in countries with low to middle Socio-demographic Index (SDI). The global prevalence of peripheral artery disease was higher in older people, (14·91% [12·41–17·87] in those aged 80–84 years), and was generally higher in females than in males. Globally, the total number of DALYs attributable to modifiable risk factors in 2019 accounted for 69·4% (64·2–74·3) of total peripheral artery disease DALYs. The prevalence of peripheral artery disease was highest in countries with high SDI and lowest in countries with low SDI, whereas DALY and mortality rates showed U-shaped curves, with the highest burden in the high and low SDI quintiles. Interpretation: The total number of people with peripheral artery disease has increased globally from 1990 to 2019. Despite the lower prevalence of peripheral artery disease in males and low-income countries, these groups showed similar DALY rates to females and higher-income countries, highlighting disproportionate burden in these groups. Modifiable risk factors were responsible for around 70% of the global peripheral artery disease burden. Public measures could mitigate the burden of peripheral artery disease by modifying risk factors. Funding: Bill & Melinda Gates Foundation.",

keywords = "Global Burden of Disease, Peripheral arterial disease",

author = "{GBD 2019 Peripheral Artery Disease Collaborators} and Kim, {Min Seo} and Jimin Hwang and Yon, {Dong Keon} and Lee, {Seung Won} and Jung, {Se Yong} and Seoyeon Park and Johnson, {Catherine Owens} and Stark, {Benjamin A.} and Christian Razo and Mohammadreza Abbasian and Hedayat Abbastabar and Abhari, {Amir Parsa} and Victor Aboyans and Adane, {Denberu Eshetie Adane} and Adebayo, {Oladimeji M.} and Fares Alahdab and Sami Almustanyir and Hany Aly and Ameyaw, {Edward Kwabena} and Anderson, {Jason A.} and Andrei, {Catalina Liliana} and Zahra Aryan and Avinash Aujayeb and Sara Bagherieh and Baltatu, {Ovidiu Constantin} and Maciej Banach and Bayileyegn, {Nebiyou Simegnew} and Bearne, {Lindsay M.} and Behnoush, {Amir Hossein} and Bensenor, {Isabela M.} and Sonu Bhaskar and Bhat, {Ajay Nagesh} and Vivek Bhat and Boris Bikbov and Bintoro, {Bagas Suryo} and Katrin Burkart and C{\'a}mera, {Luis Alberto} and Catapano, {Alberico L.} and Chandrasekar, {Eeshwar K.} and Jaykaran Charan and Chattu, {Vijay Kumar} and Gerald Chi and Chukwu, {Isaac Sunday} and Chung, {Sheng Chia} and Massimo Cirillo and Kaleb Coberly and Costa, {Vera Marisa} and Omid Dadras and Xiaochen Dai and Do, {Thanh Chi} and Rajkumar Doshi and Michael Ekholuenetale and Elgendy, {Islam Y.} and Muhammed Elhadi and Fagbamigbe, {Adeniyi Francis} and Alireza Feizkhah and Ginenus Fekadu and Gill, {Paramjit Singh} and Mohamad Goldust and Mahaveer Golechha and Guan, {Shi Yang} and Gupta, {Vivek Kumar} and Mostafa Hadei and Hadi, {Najah R.} and Ahmad Hammoud and Hankey, {Graeme J.} and Harlianto, {Netanja I.} and Hasaballah, {Ahmed I.} and Shoaib Hassan and Hassen, {Mohammed Bheser} and Golnaz Heidari and Mihaela Hostiuc and Ilesanmi, {Olayinka Stephen} and Masao Iwagami and Mohammad Jokar and Jonas, {Jost B.} and Joshua, {Charity Ehimwenma} and Jozwiak, {Jacek Jerzy} and Sina Kazemian and Mohammad Keykhaei and Amirmohammad Khalaji and Khan, {Moien A.B.} and Sorour Khateri and Kibret, {Biruk Getahun} and Oleksii Korzh and {Koulmane Laxminarayana}, {Sindhura Lakshmi} and Kewal Krishan and Akshay Kumar and Manoj Kumar and Ambily Kuttikkattu and Tri Laksono and Bagher Larijani and Le, {Thao Thi Thu} and Lim, {Stephen S.} and Xuefeng Liu and Stefan Lorkowski and {Magdy Abd El Razek}, Hassan and Kashish Malhotra and Yosef Manla and Andrea Maugeri and Mentis, {Alexios Fotios A.} and Tomislav Mestrovic and {Micheletti Gomide Nogueira de S{\'a}}, {Ana Carolina} and Andreea Mirica and Mirrakhimov, {Erkin M.} and Awoke Misganaw and Manish Mishra and Yousef Mohammad and Mokdad, {Ali H.} and Moni, {Mohammad Ali} and Montasir, {Ahmed Al} and Yousef Moradi and Paula Moraga and Negar Morovatdar and Mousavi-Aghdas, {Seyed Ali} and Murray, {Christopher J.L.} and Mohsen Naghavi and Nair, {Tapas Sadasivan} and Hasan Nassereldine and Natto, {Zuhair S.} and Nguyen, {Dang H.} and Nguyen, {Hien Quang} and Nguyen, {Van Thanh} and Noubiap, {Jean Jacques} and Bogdan Oancea and Oliveira, {Gl{\'a}ucia Maria Moraes} and Owolabi, {Mayowa O.} and Alicia Padron-Monedero and Norberto Perico and Petcu, {Ionela Roxana} and Amir Radfar and Quinn Rafferty and Mosiur Rahman and Rahman, {Muhammad Aziz} and Pradhum Ram and Sina Rashedi and Rashid, {Ahmed Mustafa} and Salman Rawaf and Giuseppe Remuzzi and Renzaho, {Andre M.N.} and Malihe Rezaee and Leonardo Roever and Saad, {Aly M.A.} and Seyedmohammad Saadatagah and Masoumeh Sadeghi and Amirhossein Sahebkar and Saleh, {Mohamed A.} and Samy, {Abdallah M.} and Santric-Milicevic, {Milena M.} and Sepanlou, {Sadaf G.} and Allen Seylani and Sadaf Sharfaei and Shorofi, {Seyed Afshin} and Singh, {Jasvinder A.} and Paramdeep Singh and Michael Spartalis and Johan Sundstr{\"o}m and Tan, {Ker Kan} and Masayuki Teramoto and Samar Tharwat and Stefanos Tyrovolas and {Valadan Tahbaz}, Sahel and {Van den Eynde}, Jef and Priya Vart and Cong Wang and Fang Wang and Ronny Westerman and Juan Xia and Suowen Xu and Yada, {Dereje Y.} and Kazumasa Yamagishi and Naohiro Yonemoto and Mazyar Zahir and Moein Zangiabadian and Armin Zarrintan and Zastrozhin, {Mikhail Sergeevich} and Anasthasia Zastrozhina and Mohammad Zoladl and Hay, {Simon I.} and Shin, {Jae Il} and Roth, {Gregory A.}",

year = "2023",

month = oct,

doi = "10.1016/S2214-109X(23)00355-8",

language = "English",

volume = "11",

pages = "e1553--e1565",

journal = "The Lancet Global Health",

issn = "2214-109X",

publisher = "Elsevier BV",

number = "10",

}

TY - JOUR

T1 - Global burden of peripheral artery disease and its risk factors, 1990–2019

T2 - a systematic analysis for the Global Burden of Disease Study 2019

AU - GBD 2019 Peripheral Artery Disease Collaborators

AU - Kim, Min Seo

AU - Hwang, Jimin

AU - Yon, Dong Keon

AU - Lee, Seung Won

AU - Jung, Se Yong

AU - Park, Seoyeon

AU - Johnson, Catherine Owens

AU - Stark, Benjamin A.

AU - Razo, Christian

AU - Abbasian, Mohammadreza

AU - Abbastabar, Hedayat

AU - Abhari, Amir Parsa

AU - Aboyans, Victor

AU - Adane, Denberu Eshetie Adane

AU - Adebayo, Oladimeji M.

AU - Alahdab, Fares

AU - Almustanyir, Sami

AU - Aly, Hany

AU - Ameyaw, Edward Kwabena

AU - Anderson, Jason A.

AU - Andrei, Catalina Liliana

AU - Aryan, Zahra

AU - Aujayeb, Avinash

AU - Bagherieh, Sara

AU - Baltatu, Ovidiu Constantin

AU - Banach, Maciej

AU - Bayileyegn, Nebiyou Simegnew

AU - Bearne, Lindsay M.

AU - Behnoush, Amir Hossein

AU - Bensenor, Isabela M.

AU - Bhaskar, Sonu

AU - Bhat, Ajay Nagesh

AU - Bhat, Vivek

AU - Bikbov, Boris

AU - Bintoro, Bagas Suryo

AU - Burkart, Katrin

AU - Cámera, Luis Alberto

AU - Catapano, Alberico L.

AU - Chandrasekar, Eeshwar K.

AU - Charan, Jaykaran

AU - Chattu, Vijay Kumar

AU - Chi, Gerald

AU - Chukwu, Isaac Sunday

AU - Chung, Sheng Chia

AU - Cirillo, Massimo

AU - Coberly, Kaleb

AU - Costa, Vera Marisa

AU - Dadras, Omid

AU - Dai, Xiaochen

AU - Do, Thanh Chi

AU - Doshi, Rajkumar

AU - Ekholuenetale, Michael

AU - Elgendy, Islam Y.

AU - Elhadi, Muhammed

AU - Fagbamigbe, Adeniyi Francis

AU - Feizkhah, Alireza

AU - Fekadu, Ginenus

AU - Gill, Paramjit Singh

AU - Goldust, Mohamad

AU - Golechha, Mahaveer

AU - Guan, Shi Yang

AU - Gupta, Vivek Kumar

AU - Hadei, Mostafa

AU - Hadi, Najah R.

AU - Hammoud, Ahmad

AU - Hankey, Graeme J.

AU - Harlianto, Netanja I.

AU - Hasaballah, Ahmed I.

AU - Hassan, Shoaib

AU - Hassen, Mohammed Bheser

AU - Heidari, Golnaz

AU - Hostiuc, Mihaela

AU - Ilesanmi, Olayinka Stephen

AU - Iwagami, Masao

AU - Jokar, Mohammad

AU - Jonas, Jost B.

AU - Joshua, Charity Ehimwenma

AU - Jozwiak, Jacek Jerzy

AU - Kazemian, Sina

AU - Keykhaei, Mohammad

AU - Khalaji, Amirmohammad

AU - Khan, Moien A.B.

AU - Khateri, Sorour

AU - Kibret, Biruk Getahun

AU - Korzh, Oleksii

AU - Koulmane Laxminarayana, Sindhura Lakshmi

AU - Krishan, Kewal

AU - Kumar, Akshay

AU - Kumar, Manoj

AU - Kuttikkattu, Ambily

AU - Laksono, Tri

AU - Larijani, Bagher

AU - Le, Thao Thi Thu

AU - Lim, Stephen S.

AU - Liu, Xuefeng

AU - Lorkowski, Stefan

AU - Magdy Abd El Razek, Hassan

AU - Malhotra, Kashish

AU - Manla, Yosef

AU - Maugeri, Andrea

AU - Mentis, Alexios Fotios A.

AU - Mestrovic, Tomislav

AU - Micheletti Gomide Nogueira de Sá, Ana Carolina

AU - Mirica, Andreea

AU - Mirrakhimov, Erkin M.

AU - Misganaw, Awoke

AU - Mishra, Manish

AU - Mohammad, Yousef

AU - Mokdad, Ali H.

AU - Moni, Mohammad Ali

AU - Montasir, Ahmed Al

AU - Moradi, Yousef

AU - Moraga, Paula

AU - Morovatdar, Negar

AU - Mousavi-Aghdas, Seyed Ali

AU - Murray, Christopher J.L.

AU - Naghavi, Mohsen

AU - Nair, Tapas Sadasivan

AU - Nassereldine, Hasan

AU - Natto, Zuhair S.

AU - Nguyen, Dang H.

AU - Nguyen, Hien Quang

AU - Nguyen, Van Thanh

AU - Noubiap, Jean Jacques

AU - Oancea, Bogdan

AU - Oliveira, Gláucia Maria Moraes

AU - Owolabi, Mayowa O.

AU - Padron-Monedero, Alicia

AU - Perico, Norberto

AU - Petcu, Ionela Roxana

AU - Radfar, Amir

AU - Rafferty, Quinn

AU - Rahman, Mosiur

AU - Rahman, Muhammad Aziz

AU - Ram, Pradhum

AU - Rashedi, Sina

AU - Rashid, Ahmed Mustafa

AU - Rawaf, Salman

AU - Remuzzi, Giuseppe

AU - Renzaho, Andre M.N.

AU - Rezaee, Malihe

AU - Roever, Leonardo

AU - Saad, Aly M.A.

AU - Saadatagah, Seyedmohammad

AU - Sadeghi, Masoumeh

AU - Sahebkar, Amirhossein

AU - Saleh, Mohamed A.

AU - Samy, Abdallah M.

AU - Santric-Milicevic, Milena M.

AU - Sepanlou, Sadaf G.

AU - Seylani, Allen

AU - Sharfaei, Sadaf

AU - Shorofi, Seyed Afshin

AU - Singh, Jasvinder A.

AU - Singh, Paramdeep

AU - Spartalis, Michael

AU - Sundström, Johan

AU - Tan, Ker Kan

AU - Teramoto, Masayuki

AU - Tharwat, Samar

AU - Tyrovolas, Stefanos

AU - Valadan Tahbaz, Sahel

AU - Van den Eynde, Jef

AU - Vart, Priya

AU - Wang, Cong

AU - Wang, Fang

AU - Westerman, Ronny

AU - Xia, Juan

AU - Xu, Suowen

AU - Yada, Dereje Y.

AU - Yamagishi, Kazumasa

AU - Yonemoto, Naohiro

AU - Zahir, Mazyar

AU - Zangiabadian, Moein

AU - Zarrintan, Armin

AU - Zastrozhin, Mikhail Sergeevich

AU - Zastrozhina, Anasthasia

AU - Zoladl, Mohammad

AU - Hay, Simon I.

AU - Shin, Jae Il

AU - Roth, Gregory A.

PY - 2023/10

Y1 - 2023/10

N2 - Background: Peripheral artery disease is a growing public health problem. We aimed to estimate the global disease burden of peripheral artery disease, its risk factors, and temporospatial trends to inform policy and public measures. Methods: Data on peripheral artery disease were modelled using the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 database. Prevalence, disability-adjusted life years (DALYs), and mortality estimates of peripheral artery disease were extracted from GBD 2019. Total DALYs and age-standardised DALY rate of peripheral artery disease attributed to modifiable risk factors were also assessed. Findings: In 2019, the number of people aged 40 years and older with peripheral artery disease was 113 million (95% uncertainty interval [UI] 99·2–128·4), with a global prevalence of 1·52% (95% UI 1·33–1·72), of which 42·6% was in countries with low to middle Socio-demographic Index (SDI). The global prevalence of peripheral artery disease was higher in older people, (14·91% [12·41–17·87] in those aged 80–84 years), and was generally higher in females than in males. Globally, the total number of DALYs attributable to modifiable risk factors in 2019 accounted for 69·4% (64·2–74·3) of total peripheral artery disease DALYs. The prevalence of peripheral artery disease was highest in countries with high SDI and lowest in countries with low SDI, whereas DALY and mortality rates showed U-shaped curves, with the highest burden in the high and low SDI quintiles. Interpretation: The total number of people with peripheral artery disease has increased globally from 1990 to 2019. Despite the lower prevalence of peripheral artery disease in males and low-income countries, these groups showed similar DALY rates to females and higher-income countries, highlighting disproportionate burden in these groups. Modifiable risk factors were responsible for around 70% of the global peripheral artery disease burden. Public measures could mitigate the burden of peripheral artery disease by modifying risk factors. Funding: Bill & Melinda Gates Foundation.

AB - Background: Peripheral artery disease is a growing public health problem. We aimed to estimate the global disease burden of peripheral artery disease, its risk factors, and temporospatial trends to inform policy and public measures. Methods: Data on peripheral artery disease were modelled using the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 database. Prevalence, disability-adjusted life years (DALYs), and mortality estimates of peripheral artery disease were extracted from GBD 2019. Total DALYs and age-standardised DALY rate of peripheral artery disease attributed to modifiable risk factors were also assessed. Findings: In 2019, the number of people aged 40 years and older with peripheral artery disease was 113 million (95% uncertainty interval [UI] 99·2–128·4), with a global prevalence of 1·52% (95% UI 1·33–1·72), of which 42·6% was in countries with low to middle Socio-demographic Index (SDI). The global prevalence of peripheral artery disease was higher in older people, (14·91% [12·41–17·87] in those aged 80–84 years), and was generally higher in females than in males. Globally, the total number of DALYs attributable to modifiable risk factors in 2019 accounted for 69·4% (64·2–74·3) of total peripheral artery disease DALYs. The prevalence of peripheral artery disease was highest in countries with high SDI and lowest in countries with low SDI, whereas DALY and mortality rates showed U-shaped curves, with the highest burden in the high and low SDI quintiles. Interpretation: The total number of people with peripheral artery disease has increased globally from 1990 to 2019. Despite the lower prevalence of peripheral artery disease in males and low-income countries, these groups showed similar DALY rates to females and higher-income countries, highlighting disproportionate burden in these groups. Modifiable risk factors were responsible for around 70% of the global peripheral artery disease burden. Public measures could mitigate the burden of peripheral artery disease by modifying risk factors. Funding: Bill & Melinda Gates Foundation.

KW - Global Burden of Disease

KW - Peripheral arterial disease

UR - http://www.scopus.com/inward/record.url?scp=85171294048&partnerID=8YFLogxK

U2 - 10.1016/S2214-109X(23)00355-8

DO - 10.1016/S2214-109X(23)00355-8

M3 - Article

C2 - 37734799

AN - SCOPUS:85171294048

SN - 2214-109X

VL - 11

SP - e1553-e1565

JO - The Lancet Global Health

JF - The Lancet Global Health

IS - 10

ER -

Global burden of peripheral artery disease and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this