Global multi-stakeholder endorsement of the MAFLD definition

Nahum Méndez-Sánchez, Elisabetta Bugianesi, Robert G. Gish, Frank Lammert, Herbert Tilg, Mindie H. Nguyen, Shiv K. Sarin, Núria Fabrellas, Shira Zelber-Sagi, Jian Gao Fan, Gamal Shiha, Giovanni Targher, Ming-Hua Zheng, Wah-Kheong Chan, Shlomo Vinker, Takumi Kawaguchi, Laurent Castera, Yusuf Yilmaz, Marko Korenjak, C. Wendy SpearmanMehmet Ungan, Melissa Palmer, Mortada El-Shabrawi, Hans Juergen Gruss, Jean François Dufour, Anil Dhawan, Heiner Wedemeyer, Jacob George, Luca Valenti, Yasser Fouad, Manuel Romero-Gomez, Mohammed Eslam, Global multi-stakeholder consensus on the redefinition of fatty liver disease, Paul N. Brennan, Gang Chen, Lei Li

Research output: Contribution to journalLetterpeer-review

180 Citations (Scopus)

Abstract

Comprising over 1000 signatories representative of multiple stakeholders, including hepatologists, internists, diabetologists, endocrinologists, paediatricians, primary-care providers, nephrologists, cardiologists, pathologists, patient advocates, nurses, nutritionists, and pharmaceutical experts from over 134 countries, we—the undersigned—endorse both the name metabolic (dysfunction)-associated fatty liver disease (MAFLD) as an overarching term and its definition for fatty liver diseases associated with metabolic dysregulation. 1 , 2 , 3 We advocate for this change because it more accurately reflects the underlying pathogenesis of the disease than does the previously used term, non-alcoholic fatty liver disease (NAFLD). Furthermore, we believe that this designation will enhance our ability to advance the science of fatty liver disease and to improve patient care. 4 , 5 This open letter represents the voices of individuals and multiple stakeholders across the global liver health community; it is not intended to devalue any other initiative, but to complement and inform them.
Original languageEnglish
Pages (from-to)388-390
Number of pages3
JournalThe Lancet Gastroenterology and Hepatology
Volume7
Issue number5
DOIs
Publication statusPublished - May 2022

Keywords

  • metabolic (dysfunction) associated fatty liver disease (MAFLD)
  • Fatty liver disease
  • metabolic dysregulation
  • stakeholders

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