TY - JOUR
T1 - Global, regional, and national burden of neurological disorders during 1990–2015
T2 - a systematic analysis for the Global Burden of Disease Study 2015
AU - GBD 2015 Neurological Disorders Collaborator Group
AU - Feigin, Valery L
AU - Abajobir, Amanuel Alemu
AU - Abate, Kalkidan Hassen
AU - Abd-Allah, Foad
AU - Abdulle, Abdishakur M
AU - Abera, Semaw Ferede
AU - Abyu, Gebre Yitayih
AU - Ahmed, Muktar Beshir
AU - Aichour, Amani Nidhal
AU - Aichour, Ibtihel
AU - Aichour, Miloud Taki Eddine
AU - Akinyemi, Rufus Olusola
AU - Alabed, Samer
AU - Al-Raddadi, Rajaa
AU - Alvis-Guzman, Nelson
AU - Amare, Azmeraw T.
AU - Ansari, Hossein
AU - Anwari, Palwasha
AU - Ärnlöv, Johan
AU - Asayesh, Hamid
AU - Asgedom, Solomon Weldegebreal
AU - Atey, Tesfay Mehari
AU - Avila-Burgos, Leticia
AU - Avokpaho, Euripide Frinel G. Arthur
AU - Azarpazhooh, Mahmood Reza
AU - Barac, Aleksandra
AU - Barboza, Miguel
AU - Barker-Collo, Suzanne L
AU - Bärnighausen, Till
AU - Bedi, Neeraj
AU - Beghi, Ettore
AU - Bennett, Derrick A
AU - Bensenor, Isabela M
AU - Berhane, Adugnaw
AU - Betsu, Balem Demtsu
AU - Bhaumik, Soumyadeep
AU - Birlik, Sait Mentes
AU - Biryukov, Stan
AU - Boneya, Dube Jara
AU - Bulto, Lemma Negesa Bulto
AU - Carabin, Hélène
AU - Casey, Daniel
AU - Castañeda-Orjuela, Carlos A.
AU - Catalá-López, Ferrán
AU - Chen, Honglei
AU - Chitheer, Abdulaal A
AU - Chowdhury, Rajiv
AU - Christensen, Hanne
AU - Dandona, Lalit
AU - Dandona, Rakhi
AU - Veber, Gabrielle A de
AU - Dharmaratne, Samath D
AU - Do, Huyen Phuc
AU - Dokova, Klara
AU - Dorsey, E Ray
AU - Ellenbogen, Richard G
AU - Eskandarieh, Sharareh
AU - Farvid, Maryam S
AU - Fereshtehnejad, Seyed-Mohammad
AU - Fischer, Florian
AU - Foreman, Kyle J
AU - Geleijnse, Johanna M
AU - Gillum, Richard F
AU - Giussani, Giorgia
AU - Goldberg, Ellen M
AU - Gona, Philimon N
AU - Goulart, Alessandra Carvalho
AU - Gugnani, Harish Chander
AU - Gupta, Rahul
AU - Hachinski, Vladimir
AU - Gupta, Rajeev
AU - Hamadeh, Randah Ribhi
AU - Hambisa, Mitiku
AU - Hankey, Graeme J
AU - Hareri, Habtamu Abera
AU - Havmoeller, Rasmus
AU - Hay, Simon I
AU - Heydarpour, Pouria
AU - Hotez, Peter J
AU - Jakovljevic, Mihajlo (Michael) B
AU - Javanbakht, Mehdi
AU - Jeemon, Panniyammakal
AU - Jonas, Jost B
AU - Kalkonde, Yogeshwar
AU - Kandel, Amit
AU - Karch, André
AU - Kasaeian, Amir
AU - Kastor, Anshul
AU - Keiyoro, Peter Njenga
AU - Khader, Yousef Saleh
AU - Khalil, Ibrahim A
AU - Khan, Ejaz Ahmad
AU - Khang, Young-Ho
AU - Khoja, Abdullah Tawfih Abdullah
AU - Khubchandani, Jagdish
AU - Kulkarni, Chanda
AU - Kim, Daniel
AU - Kim, Yun Jin
AU - Kivimaki, Mika
AU - Kokubo, Yoshihiro
AU - Kosen, Soewarta
AU - Kravchenko, Michael
AU - Krishnamurthi, Rita Vanmala
AU - Defo, Barthelemy Kuate
AU - Kumar, G Anil
AU - Kumar, Rashmi
AU - Kyu, Hmwe H
AU - Larsson, Anders
AU - Lavados, Pablo M
AU - Li, Yongmei
AU - Liang, Xiaofeng
AU - Liben, Misgan Legesse
AU - Lo, Warren D
AU - Logroscino, Giancarlo
AU - Lotufo, Paulo A
AU - Loy, Clement T
AU - Mackay, Mark T
AU - Razek, Hassan Magdy Abd El
AU - Razek, Mohammed Magdy Abd El
AU - Majeed, Azeem
AU - Malekzadeh, Reza
AU - Manhertz, Treh
AU - Mantovani, Lorenzo G
AU - Massano, João
AU - Mazidi, Mohsen
AU - McAlinden, Colm
AU - Mehata, Suresh
AU - Mehndiratta, Man Mohan
AU - Memish, Ziad A
AU - Mendoza, Walter
AU - Mengistie, Mubarek Abera
AU - Mensah, George A
AU - Meretoja, Atte
AU - Mezgebe, Haftay Berhane
AU - Miller, Ted R
AU - Mishra, Shiva Raj
AU - Ibrahim, Norlinah Mohamed
AU - Mohammadi, Alireza
AU - Mohammed, Kedir Endris
AU - Mohammed, Shafiu
AU - Mokdad, Ali H
AU - Moradi-Lakeh, Maziar
AU - Velasquez, Ilais Moreno
AU - Musa, Kamarul Imran
AU - Naghavi, Mohsen
AU - Ngunjiri, Josephine Wanjiku
AU - Nguyen, Cuong Tat
AU - Nguyen, Grant
AU - Nguyen, Quyen Le
AU - Nguyen, Trang Huyen
AU - Nichols, Emma
AU - Ningrum, Dina Nur Anggraini
AU - Nong, Vuong Minh
AU - Norrving, Bo
AU - Noubiap, Jean Jacques N
AU - Ogbo, Felix Akpojene
AU - Owolabi, Mayowa O
AU - Pandian, Jeyaraj D.
AU - Parmar, Priyakumari Ganesh
AU - Pereira, David M
AU - Petzold, Max
AU - Phillips, Michael Robert
AU - Piradov, Michael A
AU - Poulton, Richie G.
AU - Pourmalek, Farshad
AU - Qorbani, Mostafa
AU - Rafay, Anwar
AU - Rahman, Mahfuzar
AU - Rahman, Mohammad HifzUr
AU - Rai, Rajesh Kumar
AU - Rajsic, Sasa
AU - Ranta, Annemarei
AU - Rawaf, Salman
AU - Renzaho, Andre M.N.
AU - Rezai, Mohammad Sadegh
AU - Roth, Gregory A
AU - Roshandel, Gholamreza
AU - Rubagotti, Enrico
AU - Sachdev, Perminder
AU - Safiri, Saeid
AU - Sahathevan, Ramesh
AU - Sahraian, Mohammad Ali
AU - Samy, Abdallah M.
AU - Santalucia, Paula
AU - Santos, Itamar S
AU - Sartorius, Benn
AU - Satpathy, Maheswar
AU - Sawhney, Monika
AU - Saylan, Mete I
AU - Sepanlou, Sadaf G
AU - Shaikh, Masood Ali
AU - Shakir, Raad
AU - Shamsizadeh, Morteza
AU - Sheth, Kevin N
AU - Shigematsu, Mika
AU - Shoman, Haitham
AU - Silva, Diego Augusto Santos
AU - Smith, Mari
AU - Sobngwi, Eugene
AU - Sposato, Luciano A
AU - Stanaway, Jeffrey D
AU - Stein, Dan J
AU - Steiner, Timothy J
AU - Stovner, Lars Jacob
AU - Abdulkader, Rizwan Suliankatchi
AU - Szoeke, Cassandra EI
AU - Tabarés-Seisdedos, Rafael
AU - Tanne, David
AU - Theadom, Alice M
AU - Thrift, Amanda G
AU - Tirschwell, David L
AU - Topor-Madry, Roman
AU - Tran, Bach Xuan
AU - Truelsen, Thomas
AU - Tuem, Kald Beshir
AU - Ukwaja, Kingsley Nnanna
AU - Uthman, Olalekan A
AU - Varakin, Yuri Y
AU - Vasankari, Tommi
AU - Venketasubramanian, Narayanaswamy
AU - Vlassov, Vasiliy Victorovich
AU - Wadilo, Fiseha
AU - Wakayo, Tolassa
AU - Wallin, Mitchell T
AU - Weiderpass, Elisabete
AU - Westerman, Ronny
AU - Wijeratne, Tissa
AU - Wiysonge, Charles Shey
AU - Woldu, Minyahil Alebachew
AU - Wolfe, Charles D A
AU - Xavier, Denis
AU - Xu, Gelin
AU - Yano, Yuichiro
AU - Yimam, Hassen Hamid
AU - Yonemoto, Naohiro
AU - Yu, Chuanhua
AU - Zaidi, Zoubida
AU - Zaki, Maysaa El Sayed
AU - Zunt, Joseph R
AU - Murray, Christopher J L
AU - Vos, Theo
PY - 2017/11
Y1 - 2017/11
N2 - Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 million]), and Alzheimer's disease and other dementias (46·0 [40·2 to 52·7 million]). Between 1990 and 2015, the number of deaths from neurological disorders increased by 36·7%, and the number of DALYs by 7·4%. These increases occurred despite decreases in age-standardised rates of death and DALYs of 26·1% and 29·7%, respectively; stroke and communicable neurological disorders were responsible for most of these decreases. Communicable neurological disorders were the largest cause of DALYs in countries with low SDI. Stroke rates were highest at middle levels of SDI and lowest at the highest SDI. Most of the changes in DALY rates of neurological disorders with development were driven by changes in YLLs. Interpretation Neurological disorders are an important cause of disability and death worldwide. Globally, the burden of neurological disorders has increased substantially over the past 25 years because of expanding population numbers and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders. The number of patients who will need care by clinicians with expertise in neurological conditions will continue to grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate services. Funding Bill & Melinda Gates Foundation.
AB - Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 million]), and Alzheimer's disease and other dementias (46·0 [40·2 to 52·7 million]). Between 1990 and 2015, the number of deaths from neurological disorders increased by 36·7%, and the number of DALYs by 7·4%. These increases occurred despite decreases in age-standardised rates of death and DALYs of 26·1% and 29·7%, respectively; stroke and communicable neurological disorders were responsible for most of these decreases. Communicable neurological disorders were the largest cause of DALYs in countries with low SDI. Stroke rates were highest at middle levels of SDI and lowest at the highest SDI. Most of the changes in DALY rates of neurological disorders with development were driven by changes in YLLs. Interpretation Neurological disorders are an important cause of disability and death worldwide. Globally, the burden of neurological disorders has increased substantially over the past 25 years because of expanding population numbers and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders. The number of patients who will need care by clinicians with expertise in neurological conditions will continue to grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate services. Funding Bill & Melinda Gates Foundation.
KW - Global Burden of Disease
KW - GBD
KW - Neurological disorders
UR - http://www.scopus.com/inward/record.url?scp=85029494753&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(17)30299-5
DO - 10.1016/S1474-4422(17)30299-5
M3 - Article
C2 - 28931491
AN - SCOPUS:85029494753
VL - 16
SP - 877
EP - 897
JO - Lancet Neurology
JF - Lancet Neurology
SN - 1474-4422
IS - 11
ER -