GLP-1 appetite control via intestinofugal neurons

Research output: Contribution to journalComment/debate

Abstract

The gut hormone glucagon-like peptide-1 (GLP-1) holds significant therapeutic interest for glycaemic and appetite control, but an endocrine role has been questioned, since GLP-1 is broken down rapidly in the bloodstream. A major new study by Zhang et al., identifies that a unique neuronal population within the enteric nervous system, whose axons leave the gut wall and activate sympathetic prevertebral neurons, links intestinal GLP-1 to gastric distension and acute appetite suppression, that characterizes a gastrointestinal behavior known as the “ileal brake”.
Original languageEnglish
Pages (from-to)711–712
Number of pages2
JournalCELL RESEARCH
Volume32
Issue number8
Early online date6 Jul 2022
DOIs
Publication statusPublished - Aug 2022

Keywords

  • glucagon-like peptide-1 (GLP-1)
  • glycaemic control
  • appetite control
  • ileal brake
  • Intestinofugal neurons (IFNs)

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