Abstract
The gut hormone glucagon-like peptide-1 (GLP-1) holds significant therapeutic interest for glycaemic and appetite control, but an endocrine role has been questioned, since GLP-1 is broken down rapidly in the bloodstream. A major new study by Zhang et al., identifies that a unique neuronal population within the enteric nervous system, whose axons leave the gut wall and activate sympathetic prevertebral neurons, links intestinal GLP-1 to gastric distension and acute appetite suppression, that characterizes a gastrointestinal behavior known as the “ileal brake”.
Original language | English |
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Pages (from-to) | 711–712 |
Number of pages | 2 |
Journal | CELL RESEARCH |
Volume | 32 |
Issue number | 8 |
Early online date | 6 Jul 2022 |
DOIs |
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Publication status | Published - Aug 2022 |
Keywords
- glucagon-like peptide-1 (GLP-1)
- glycaemic control
- appetite control
- ileal brake
- Intestinofugal neurons (IFNs)