The gut hormone glucagon-like peptide-1 (GLP-1) holds significant therapeutic interest for glycaemic and appetite control, but an endocrine role has been questioned, since GLP-1 is broken down rapidly in the bloodstream. A major new study by Zhang et al., identifies that a unique neuronal population within the enteric nervous system, whose axons leave the gut wall and activate sympathetic prevertebral neurons, links intestinal GLP-1 to gastric distension and acute appetite suppression, that characterizes a gastrointestinal behavior known as the “ileal brake”.
- glucagon-like peptide-1 (GLP-1)
- glycaemic control
- appetite control
- ileal brake
- Intestinofugal neurons (IFNs)